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Phthalylsulfathiazole

CAS No.85-73-4
Chemical Name:Phthalylsulfathiazole
CBNumber:CB2405964
Molecular Formula:C17H13N3O5S2
Formula Weight:403.43
MOL File:85-73-4.mol

Phthalylsulfathiazole Property

Melting point 198-204°C
Boiling point 371.31℃[at 101 325 Pa]
Density 1.4235 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.6390 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Practically insoluble in water, freely soluble in dimethylformamide, slightly soluble in acetone and in ethanol (96 per cent).
form Solid
pka 3.40±0.36(Predicted)
color White to Light Yellow
biological source rabbit
Water Solubility 400mg/L at 28℃
Merck 14,7377
BRN 359901
LogP -2 at 28℃
CAS DataBase Reference 85-73-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 6875L5852V
ATC code A07AB02
NIST Chemistry Reference Phthalylsulfathiazole(85-73-4)
EPA Substance Registry System Benzoic acid, 2-[[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]carbonyl]- (85-73-4)
UNSPSC Code 41116107
NACRES NA.41

Safety

Safety Statements :24/25
RIDADR :3249
RTECS :TH8575000
HazardClass :6.1(b)
PackingGroup :III
HS Code :29350090
Toxicity :LD50 i.p. in mice: 920 mg/kg (Mattis)

NFPA 704:

	0
0		1

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H412
Precautionary statements P273-P501

Phthalylsulfathiazole Price More Price(7)

Brand: Sigma-Aldrich(India)
Product number: WH0006817M1
Product name : Monoclonal Anti-SULT1A1 antibody produced in mouse
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Product number: HPA053995
Product name : Anti-ST8SIA4 antibody produced in rabbit
Purity: Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody
Packaging: 100μL
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Brand: Sigma-Aldrich(India)
Product number: HPA051126
Product name : Anti-ST8SIA4 antibody produced in rabbit
Purity: Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Packaging: 100μL
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Brand: Sigma-Aldrich(India)
Product number: HPA049500
Product name : Anti-SULT1A1 antibody produced in rabbit
Purity: Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Packaging: 100μL
Price: ₹41436.3
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: AV49134
Product name : Anti-SULT1A1 antibody produced in rabbit
Purity: affinity isolated antibody
Packaging: 100μL
Price: ₹48873.3
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Phthalylsulfathiazole Chemical Properties,Usage,Production

Chemical Properties White or yellowish-white, crystalline powder.
Originator Sulfathalidine, MSD, US,1946
Uses Phthalylsulfathiazole is a sulfonamide antibacterial drug with similar and stronger effects than Sulfaguanidine and Succinylsulfathiazole. It is rarely absorbed orally and slowly decomposes in the intestine to release Sulfathiazole and exert intestinal antibacterial effects, and is used in the treatment of dysentery, colitis, and gastroenteritis.
Definition ChEBI: Phthalylsulfathiazole is a sulfonamide incorporating 2-carboxybenzamido and 1,3-thiazol-2-yl moieties that is a broad-spectrum antibiotic indicated in the treatment of dysentery, colitis, gastroenteritis and intestinal surgery. It is a sulfonamide, a member of 1,3-thiazoles, a dicarboxylic acid monoamide and a sulfonamide antibiotic. It derives from a phthalic acid.
Preparation It may be prepared by the interaction of sulfathiazole and phthalic anhydride in equimolar proportions.
It exerts its bacteriostatic effect in the gastro-intestinal tract. It has been found to be twice as active as sulfaguanidine in the treatment of bowel irregularities. It is often effective in watery diarrhoeas and ulcerative colitis. It is also used in the pre-operative treatment of patients undergoing surgery of the intestinal tract. It may also be recommended in the treatment of acute bascillary dysentry of the Sonne, Flexner and Shiga species.
Manufacturing Process 5 g of phthalic anhydride was added to a boiling suspension of 10 g of sulfathiazole in 100 cc of alcohol. The mixture was then refluxed for 5 minutes after the addition was complete at which time all of the solids were in solution. The solution was then cooled and diluted with an equal volume of water, The white solid precipitate which formed was filtered and recrystallized from dilute alcohol, yielding 2-N4-phthalylsulfanilamidothiazole,which decomposes above 260°C, according to US Patent 2,324,015.
brand name Canidis-anti-diarr;Carbidiar;Carbotalin;Colicitina;Coliclase;Crematalil;Diacolin;Direver;Disenterol;Ef-micin;Enterocalme;Entero-hermes;Entero-red;Enterosteril;Entero-toxan;Esteraplidin mag;Eugeniteed;Fitazil;Ftalil-tiazol;Ilentazol;Inrestibla strepto;Iodentero-neomicina;Logical;Massotalil;Neo-sulfazon;Novosulfina;Phtazol;Septiftalil;Syptan;Talisulfazol;Tamil;.
Therapeutic Function Antibacterial (intestinal)
World Health Organization (WHO) Phthalylsulfathiazole, a sulfonamide anti-infective agent, was introduced in 1946 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. Although phthalylsulfathiazole, which is poorly absorbed from the gastrointestinal tract, is no longer recommended in some countries, it continues to be used in others for the treatment of local intestinal infections, including bacterial dysentery, and for pre-operative bowel preparation.
Flammability and Explosibility Non flammable
Biological Activity Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (SULT1A1) is a phenol sulfotransferase with thermostable activity. The members of sulfotransferase family localize to cytoplasm and catalyze the sulfate conjugation of hormones, xenobiotic compounds, drugs and neurotransmitters.
Mode of action Phthalylsulfathiazole is of low inherent toxicity. Besides, it also enjoys an additional plus point for being only slightly absorbed by the intestinal mucosa ; and, therefore, may be safely administered in comparatively large doses in the management and treatment of bacillary infections of the intestine. The drug is not absorbed orally and is mostly employed for ulcerative colitis.