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Dibenzoylmethane

CAS No.120-46-7
Chemical Name:Dibenzoylmethane
CBNumber:CB7175433
Molecular Formula:C15H12O2
Formula Weight:224.25
MOL File:120-46-7.mol

Dibenzoylmethane Property

Melting point 77-79 °C(lit.)
Boiling point 219-221 °C18 mm Hg(lit.)
Density 0.800 g/cm3
vapor pressure 0.01Pa at 20℃
refractive index 1.6600 (estimate)
Flash point 219-221°C/18mm
storage temp. Store below +30°C.
solubility Chloroform (Slightly), Methanol (Slightly, Sonicated)
pka 8.95±0.10(Predicted)
form Crystals
color Light yellow to yellow
Water Solubility It is Soluble in ether, chloroform, and aqueous sodium hydroxide. Insoluble in water.
Merck 14,3009
BRN 514910
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey NZZIMKJIVMHWJC-UHFFFAOYSA-N
LogP 4.59 at 25℃
CAS DataBase Reference 120-46-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII ANS7ME8OKC
NIST Chemistry Reference 1,3-Propanedione, 1,3-diphenyl-(120-46-7)
EPA Substance Registry System 1,3-Propanedione, 1,3-diphenyl- (120-46-7)
UNSPSC Code 12352115
NACRES NA.22

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :22-24/25
WGK Germany :3
RTECS :TZ1930000
Hazard Note :Irritant
TSCA :Yes
HS Code :29143900
Toxicity :rat,LD,oral,> 500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 28, 1953.

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P271-P280

Dibenzoylmethane Price More Price(15)

Brand: Sigma-Aldrich(India)
Product number: D33454
Product name : 1,3-Diphenyl-1,3-propanedione
Purity: 98%
Packaging: 25G
Price: ₹2511.4
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: D33454
Product name : 1,3-Diphenyl-1,3-propanedione
Purity: 98%
Packaging: 100G
Price: ₹7555.85
Updated: 2022/06/14
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Brand: ALFA India
Product number: ALF-A13450-36
Product name : 1,3-Diphenyl-1,3-propanedione, 98+%
Purity:
Packaging: 500g
Price: ₹21411
Updated: 2022/05/26
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Brand: TCI Chemicals (India)
Product number: D0910
Product name : 1,3-Diphenyl-1,3-propanedione
Purity: min. 98.0 %
Packaging: 25G
Price: ₹3200
Updated: 2022/05/26
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Brand: ALFA India
Product number: ALF-A13450-22
Product name : 1,3-Diphenyl-1,3-propanedione, 98+%
Purity:
Packaging: 100g
Price: ₹6163
Updated: 2022/05/26
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Dibenzoylmethane Chemical Properties,Usage,Production

Chemical Properties Dibenzoylmethane (DB), a minor constituent of the root extract of licorice, belongs to the flavonoid family. It is a colorless rhombus flake crystal or yellowish-white powder. soluble in chlorohydrin and chloroform, soluble in sodium hydroxide solution, insoluble in sodium carbonate solution, and very slightly soluble in water. It is used as a colorimetric reagent for the determination of uranium.
Occurrence Dibenzoylmethane(DBM) is a 1,3-diketone derivative of acetylacetone that has both methyl groups replaced with phenyl groups.Although smaller in size and lacking hydroxyl and methoxy groups，DBM resembles the turmeric spice curcumin (CUR),a diferuloylmethane. Both molecules are metal-chelating agents，contain a B-diketone flanked by two aryl groups,and exhibit anti-proliferative and anticarcinogenic activity. In addition to sharing structural similarity with DBM,CUR,which is also a naturally occurring compound is found in the plant Curcuma longa and has numerous medicinal uses.
DBM and its many naturally occurring derivatives are minor constituentsof licorice. DBM has been isolated from licorice root extracts and otherspecies of Glycyrrhiza.
Uses Dibenzoylmethane is a new kind of PVC heat stabilizer, it has better transparency, nontoxic and odorless. In case of combined use with Calcium/Zinc, Barium/Zin and other heat stabilizer, it can greatly improve the initial color, transparency, long term stability of PVC, and also can improve the precipitation and “zinc burning” problem during the process. It has very good synergy with zinc soaps, and can protect the PVC color. This material can absorb UV at 290nm, which has the effect as light stabilizer and act as long term stabilizer for PVC products.
Uses Dibenzoylmethane is a compound known to inhibit tumorigenesis in mice.
Definition ChEBI: Dibenzoylmethane is a beta-diketone that is acetylacetone (acac) in which both methyl groups have been replaced by phenyl groups. It is a minor constituent of the root extract of licorice (Glycyrrhiza glabra) and exhibits antimutagenic and anticancer effects. It has a role as an antineoplastic agent, a metabolite and an antimutagen. It is a beta-diketone and an aromatic ketone.
Preparation dibenzoylmethane is prepared by condensation of ethyl benzoate with acetophenone.
Synthesis Reference(s) Tetrahedron Letters, 37, p. 3885, 1996 DOI: 10.1016/0040-4039(96)00689-2
Chemical and Pharmaceutical Bulletin, 29, p. 2762, 1981 DOI: 10.1248/cpb.29.2762
Flammability and Explosibility Non flammable
Safety Profile Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors
Purification Methods Dibenzoylmethane (1,3-diphenyl-1,3-propanedione) [120-46-7] M 224.3, m 8 0o. Crystallise dibenzoylmethane from pet ether or MeOH. [Beilstein 7 IV 2512.]