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(1R,2S,3S)-Aprepitant

(1R,2S,3S)-Aprepitant Structure
(1R,2S,3S)-Aprepitant
  • CAS No.172822-28-5
  • Chemical Name:(1R,2S,3S)-Aprepitant
  • CBNumber:CB23146512
  • Molecular Formula:C23H21F7N4O3
  • Formula Weight:534.43
  • MOL File:172822-28-5.mol
(1R,2S,3S)-Aprepitant Property
  • Density 1.51±0.1 g/cm3(Predicted)
  • pka 8.06±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

(1R,2S,3S)-Aprepitant Chemical Properties,Usage,Production

  • Uses (2S,3S,1’R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. (2S,3S,1’R)-Aprepitant is also a useful synthetic intermediate in the synthesis of morpholine tachykinin receptor antagonist prodrugs.
(1R,2S,3S)-Aprepitant Preparation Products And Raw materials
Raw materials
Preparation Products
(1R,2S,3S)-Aprepitant Suppliers
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(1R,2S,3S)-Aprepitant Spectrum
172822-28-5, (1R,2S,3S)-AprepitantRelated Search:
  • 杂质对照品
  • 对照品-杂质对照品
  • 福沙匹坦双葡甲胺INT1-SSR
  • 阿瑞匹坦RSS杂质
  • 阿瑞吡坦杂质6(R,S,S异构体)
  • 阿瑞吡坦杂质5
  • 5[[(2S,3S)- 2[(1R)- 1 –[3,5-二(三氟甲基)苯基]乙氧基]
  • (1R,2S,3S)-阿瑞吡坦
  • SM001F(福沙匹坦杂质SSR)
  • SM001F
  • APREPITANT(R,S,S)-异构体
  • (1R,2S,3S)-阿瑞匹坦
  • 瑞匹坦杂质3
  • 172822-28-5
  • 3H-1,2,4-Triazol-3-one, 5-[[(2S,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-
  • Aprepitant (R,S,S)-Isomer
  • (R,S,S)-Enantiomer Aprepitant
  • Aprepitant Impurity 6(R,S,S-Isomer)
  • Aprepitant impurity 7/(1R,2S,3S)-Aprepitant
  • Aprepitant Intermediate Impurity -(RSS)
  • Aprepitant Impurity - (RSS)
  • (2S,3S,1’R)-Aprepitant
  • SM001F
  • 3H-1,2,4-Triazol-3-one, 5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-, [2S-[2α(S*),3β]]- (9CI)
  • 5-([(2S,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one
  • Aretetan Impurity-(RSS)

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