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Phenytoin sodium

Phenytoin sodium Structure
Phenytoin sodium
  • CAS No.630-93-3
  • Chemical Name:Phenytoin sodium
  • CBNumber:CB2304645
  • Molecular Formula:C15H13N2NaO2
  • Formula Weight:276.27
  • MOL File:630-93-3.mol
Phenytoin sodium Property
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22-43-62-63
  • Safety Statements  :22-36/37/39-45
  • RIDADR  :UN 2811 6.1/PG 3
  • WGK Germany  :3
  • RTECS  :MU1400000
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :29332100
  • Toxicity :LD50 orally in mice: 490 mg/kg (Fink, Swinyard)
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H317-H361
  • Precautionary statements P201-P202-P280-P301+P312-P302+P352-P308+P313
Phenytoin sodium Price More Price(5)
  • Brand: Sigma-Aldrich(India)
  • Product number: D4505
  • Product name : 5,5-Diphenylhydantoin sodium salt
  • Purity: ≥99%
  • Packaging: 25G
  • Price: ₹6040.35
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: PHR1492
  • Product name : Phenytoin sodium
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging: 1G
  • Price: ₹9103.83
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D4505
  • Product name : 5,5-Diphenylhydantoin sodium salt
  • Purity: ≥99%
  • Packaging: 100G
  • Price: ₹10597.68
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D1331
  • Product name : Phenytoin Sodium
  • Purity: 
  • Packaging: 25G
  • Price: ₹3400
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D1331
  • Product name : Phenytoin Sodium
  • Purity: 
  • Packaging: 500G
  • Price: ₹11700
  • Updated: 2022/05/26
  • Buy: Buy

Phenytoin sodium Chemical Properties,Usage,Production

  • Chemical Properties White or almost white, crystalline powder, slightly hygroscopic.
  • Uses antibacterial
  • Uses 5,5-Diphenylhydantoin sodium salt has been used:
    • in the cream preparation for treating burn wounds
    • in seizure behavior testing as an anticonvulsant in Drosophila
    • in in vivo embryo toxicity test in mouse embryonic stem cells

  • Uses Antiepileptic
  • brand name Diphenylan (Lannett); Phenytek (Mylan); Phenytex (Watson) [Name previously used: Diphenylhydantoin Sodium.].
  • General Description Phenytoin sodium, 5,5-diphenyl-2,4-imidazolidinedione, 5,5-diphenylhydantoin,diphenyl-hydantoin sodium (Dilantin), has been used fordecades in the control of grand mal types of epilepticseizure. It is structurally analogous to the barbiturates butdoes not possess their extensive sedative properties. Thecompound is available as the sodium salt. Solutions for parenteraladministration contain 40% propylene glycol and10% alcohol to dissolve the sodium salt.
  • Biological Activity Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels.
  • Clinical Use Phenytoin sodium’s cardiovascular effects were uncoveredduring observation of toxic manifestations of the drugin patients being treated for seizure disorders. Phenytoinsodium was found to cause bradycardia, prolong the PRinterval, and produce T-wave abnormalities on electrocardiograms.It is a class IB antiarrhythmic agent. Today,phenytoin sodium’s greatest clinical use as an antiarrhythmicdrug is in the treatment of digitalis-induced arrhythmias.34 Its action is similar to that of lidocaine. It depressesventricular automaticity produced by digitalis, without adverseintraventricular conduction. Because it also reversesthe prolongation of AV conduction by digitalis, phenytoinsodium is useful in supraventricular tachycardias caused bydigitalis intoxication.
  • Safety Profile Confirmed carcinogen. Experimental teratogen. Other experimental reproductive effects. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: anorexia, respiratory depression, nausea or vomiting, hemorrhage, dermatitis, and endocrine effects. Mutation data reported. An anticonvulsant and cardiac depressant used for the treatment of grand mal and psychomotor seizures. When heated to decomposition it emits very toxic fumes of NOx and Na2O.
  • Carcinogenicity Phenytoin and its sodium salt are reasonably anticipated to be human carcinogens based on sufficient evidence from studies in experimental animals.
  • Solubility in water 1 g dissolves in ca. 66 ml of water. The aqueous solution is turbid unless the pH is adjusted above 11.7, which is the pH of the saturated solution. 1 g dissolves in 10.5 mL of alcohol. Practically insoluble in ether and chloroform.
  • Toxics Screening Level The IRSL for Dilantin is 0.07 μg/m3.
Phenytoin sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Phenytoin sodium Suppliers
Global(448)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
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  • Advantage：55
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    career henan chemical co
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Phenytoin sodium Spectrum
630-93-3, Phenytoin sodiumRelated Search:
  • Sodium channel
  • Typical Metal Compounds
  • Na (Sodium) Compounds (excluding simple sodium salts)
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  • Na (Sodium) Compounds (excluding simple sodium salts)
  • Typical Metal Compounds
  • Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels.
  • C15H12N2NaO2
  • C15H11N2O2Na
  • C15H12N2O2Na
  • C15H11NaN2O2
  • C15H11N2NaO2
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