ChemicalBook > CAS DataBase List > ST638

ST638

CAS No.107761-24-0
Chemical Name:ST638
CBNumber:CB2285405
Molecular Formula:C19H18N2O3S
Formula Weight:354.42
MOL File:107761-24-0.mol

ST638 Property

Melting point 134-135.5 °C
Boiling point 611.2±55.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility DMSO: 19 mg/mL
pka 8.79±0.50(Predicted)
form solid
color yellow
FDA UNII 6X89Y2007R
UNSPSC Code 12352200
NACRES NA.77

Safety

WGK Germany :3
RTECS :UC6316200

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302
Precautionary statements P264-P270-P301+P312-P330-P501

ST638 Price More Price(1)

Brand: Sigma-Aldrich(India)
Product number: S1195
Product name : ST638
Purity: ≥98% (HPLC), solid
Packaging: 5MG
Price: ₹23663.45
Updated: 2022/06/14
Buy: Buy

ST638 Chemical Properties,Usage,Production

Uses ST638 is a protein tyrosine kinase inhibitor and PLD inhibitor.
Biological Activity st638 is a tyrosine kinase inhibitor [1].tyrosine kinases are a family of protein kinases that phosphorylate the serine and threonine on other proteins. phosphorylation of proteins by kinases has been involved in signal transduction and regulating cellular activity, such as cell division. tyrosine kinases function in a variety of processes, such as mitogenesis, induction of mitosis, and transmembrane signaling [2].in human platelets, preincubation with 50 μm of st638 completely blocked the platelet aggregation induced with 0.05 unit/ml of thrombin. st638 inhibited the increase of protein-tyrosine phosphorylation bands induced with thrombin in a dose-dependent manner. st638 blocked the platelet aggregation and protein-tyrosine phosphorylation induced with thrombin in aspirin-treated platelets [1]. in terminal erythroid differentiation of mouse erythroleukemia (mel) cells, st638 effectively induced differentiation in a synergistic manner [3]. in rat and rabbit pulmonary artery cells, st 638 (0.5 to 40 μmol/l) blocked ik in a dose-dependent manner [4].
References [1] asahi m, yanagi s, ohta s, et al. thrombin-induced human platelet aggregation is inhibited by protein-tyrosine kinase inhibitors, st638 and genistein[j]. febs letters, 1992, 309(1): 10-14.
[2] levitzki a, gazit a. tyrosine kinase inhibition: an approach to drug development[j]. science, 1995, 267(5205): 1782.
[3] watanabe t, shiraishi t, sasaki h, et al. inhibitors for protein-tyrosine kinases, st638 and genistein, induce differentiation of mouse erythroleukemia cells in a synergistic manner[j]. experimental cell research, 1989, 183(2): 335-342.
[4] smirnov s v, aaronson p i. inhibition of vascular smooth muscle cell k+ currents by tyrosine kinase inhibitors genistein and st 638[j]. circulation research, 1995, 76(2): 310-316.

ST638 Preparation Products And Raw materials

Raw materials

Preparation Products

ST638 Suppliers

Global(52)Suppliers