[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane

[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane Structure
[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane
  • CAS No.536975-50-5
  • Chemical Name:[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane
  • CBNumber:CB22644992
  • Molecular Formula:C10H14F2O2SSi
  • Formula Weight:264.36
  • MOL File:536975-50-5.mol
[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane Property
  • Boiling point 96-97 °C(Press: 1 Torr)
  • Density 1.162±0.06 g/cm3(Predicted)
Safety
  • Safety Statements  :24/25
  • HS Code  :29350090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane Chemical Properties,Usage,Production

  • Description A much milder difluoro(phenylsulfonyl)methylation reagent than difluoromethyl phenyl sulfone. Under the action of Lewis bases such as such as tetrabutylammonium triphenyldifluorosilicate (TBAT), potassium fluoride, potassium hydrodifluoride, and potassium carbonate, difluoro(phenylsulfonyl)methyl can be transferred to aldehydes, ketones, alkyl halides, and non-activated imines.
  • Reactions (1) Difluoromethylation of aldehydes and ketones.
    Difluoromethylation of aldehydes and ketones.
    (2) Difluoromethylation of alkyl halides.
    Difluoromethylation of alkyl halides
    (3) Difluoromethylation of imines and enamines.
    Difluoromethylation of imines and enamines
  • References [1] H. TOMIOKA. Selective oxidation of a primary hydroxyl in the presence of secondary one[J]. Tetrahedron Letters, 1981, 49 1: 1605-1608. DOI:10.1016/S0040-4039(01)90389-2
    [2] LINGUI ZHU. Nucleophilic (phenylsulfonyl)difluoromethylation of alkyl halides using PhSO2CF2SiMe3: preparation of gem-difluoroalkenes and trifluoromethyl compounds[J]. Tetrahedron Letters, 2010, 51 47: Pages 6150-6152. DOI:10.1016/j.tetlet.2010.09.068.
    [3] MIKHAIL D. KOSOBOKOV. Reactions of Sulfur- and Phosphorus-Substituted Fluoroalkylating Silicon Reagents with Imines and Enamines under Acidic Conditions[J]. The Journal of Organic Chemistry, 2012, 77 4: 2080-2086. DOI:10.1021/jo202669w.
[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane Preparation Products And Raw materials
Raw materials
Preparation Products
[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane Suppliers
Global(24)Suppliers
  • Supplier： J & K SCIENTIFIC LTD.
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  • Email：jkinfo@jkchemical.com
  • Country：China
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[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane Spectrum
  • C10H14F2O2SSi
  • 二氟(苯基磺酰基)甲基]三甲基硅烷
  • (二氟(苯磺酰基)甲基)三甲基硅烷
  • 二氟(三甲基硅基)甲基]磺酰]-苯
  • 二氟(苯磺酰)】三甲基硅烷
  • [二氟(苯磺酰)甲基]三甲基硅烷
  • 536975-50-5
  • Benzene, [[difluoro(trimethylsilyl)methyl]sulfonyl]-
  • Difluoro(trimethylsilyl)methyl]sulfonyl]-benzene
  • [difluoro(phenylsulfonyl)Methyl]triMethyl-Silane

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