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(4S)-4-hydroxy-L-proline hydrochloride

(4S)-4-hydroxy-L-proline hydrochloride Structure
(4S)-4-hydroxy-L-proline hydrochloride
  • CAS No.441067-49-8
  • Chemical Name:(4S)-4-hydroxy-L-proline hydrochloride
  • CBNumber:CB22549600
  • Molecular Formula:C5H10ClNO3
  • Formula Weight:167.5908
  • MOL File:441067-49-8.mol
(4S)-4-hydroxy-L-proline hydrochloride Property
  • storage temp. Inert atmosphere,Room Temperature
  • form Solid
  • color White to light yellow
Safety
  • HazardClass  :IRRITANT
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

(4S)-4-hydroxy-L-proline hydrochloride Chemical Properties,Usage,Production

  • Uses cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
  • IC 50 Non-cleavable Linker
  • References [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
    [2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
(4S)-4-hydroxy-L-proline hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(4S)-4-hydroxy-L-proline hydrochloride Suppliers
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(4S)-4-hydroxy-L-proline hydrochloride Spectrum
441067-49-8, (4S)-4-hydroxy-L-proline hydrochlorideRelated Search:
  • 抑制剂
  • 氨基酸及其衍生物
  • 化合物 CIS-4-HYDROXY-L-PROLINE HYDROCHLORIDE
  • CIS-4-羟基-L-脯氨酸盐酸盐
  • (2S,4S)-顺式-4-羟基-L-脯氨酸盐酸盐
  • 顺式-4-羟基-L-脯氨酸盐酸盐(CAS号:441067-49-8)
  • (2S,4S)-4-羟基吡咯烷-2-羧酸盐酸盐
  • (4S)-4-羟基-L-脯氨酸盐酸盐
  • 441067-49-8
  • (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid Hydrochloride/cis-4-Hydroxy-L-proline hydrochloride
  • (2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride , H-cis-Hyp-OH·HCl
  • (4S)-4-hydroxy-L-Proline hydrochloride (1:1)
  • (4S)-4-Hydroxy-L-Proline HCl
  • (4S)-4-hydroxy-L-proline hydrochloride USP/EP/BP
  • (2S,4S)-cis-4-hydroxy-L-proline hydrochloride
  • L-Proline, 4-hydroxy-, hydrochloride, (4S)-
  • Cis-4-hydroxy-L-prolineMonohydrochloride
  • (2s,4S)-4-hydroxy-L-proline hydrochloride
  • cis-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride
  • H-cis-Hyp-OH·HCl
  • L-Proline,4-hydroxy-,hydrochloride(1:1),(4S)-
  • L-Proline, 4-hydroxy-,hydrochloride, cis-
  • (4S)-4-hydroxy-L-proline hydrochloride

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