ChemicalBook > CAS DataBase List > N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide

N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide

N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide Structure
N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide
  • CAS No.178870-32-1
  • Chemical Name:N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide
  • CBNumber:CB21455999
  • Molecular Formula:C17H18ClNO2S
  • Formula Weight:335.85
  • MOL File:178870-32-1.mol
N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide Property
  • Boiling point 440.9±55.0 °C(Predicted)
  • Density 1.240±0.06 g/cm3(Predicted)
  • pka 9.78±0.70(Predicted)
  • FDA UNII L7K247H29H
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide Chemical Properties,Usage,Production

  • Uses UC-781 (NSC 675186) is a highly potent and selective nonnucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an IC50 value of 5 nM. UC-781 is stable under low PH or various temperatures conditions. UC-781 has antiviral activity and resistance[1][2][3].
  • in vivo

    UC-781 (100 μl 5% UC-781 replens gel; intravaginal; once daily for 10 days) releases from gel preparation and shows low toxicity to normal tissues in female rabbit[1].

    Animal Model:Female rabbit (~1200 g; 10 weeks old)[1].
    Dosage:100 μl 5% UC-781 replens gel.
    Administration:Intravaginal; once daily for 10 days.
    Result:Released from gel preparation and had normal histology without significant increases inflammatory cells in rabbits.
  • IC 50 HIV-1: 0.005 μM (IC50)
  • References [1] Balzarini J, et al. Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent. AIDS. 1998 Jul 9;12(10):1129-38. DOI:10.1097/00002030-199810000-00004
    [2] Van Herrewege Y, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48(1):337-9. DOI:10.1128/AAC.48.1.337-339.2004
    [3] Balzarini J, et al. Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication. Mol Pharmacol. 1996 Aug;50(2):394-401. PMID:8700148
    [4] Fletcher P, et al. The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells. J Virol. 2005 Sep;79(17):11179-86. DOI:10.1128/JVI.79.17.11179-11186.2005
N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide Suppliers
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N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide Spectrum
178870-32-1, N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamideRelated Search:
  • 抑制剂
  • 化合物 UC-781
  • N-(4-氯-3-((3-甲基丁-2-烯-1-基)氧基)苯基)-2-甲基呋喃-3-硫代甲酰胺
  • 化合物 T29037
  • 178870-32-1
  • 3-Furancarbothioamide, N-[4-chloro-3-[(3-methyl-2-buten-1-yl)oxy]phenyl]-2-methyl-
  • Thiocarboxanilide
  • Nsc675186
  • N-[4-Chloro-3-(3-methyl-2-butenyloxy)phenyl]-2-methyl-3-furancarbothioamide
  • Aids-029940
  • Aids029940
  • N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide

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