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Alendronate sodium

CAS No.121268-17-5
Chemical Name:Alendronate sodium
CBNumber:CB2145121
Molecular Formula:C4H13NO7P2.3H2O.Na
Formula Weight:326.13
MOL File:121268-17-5.mol

Alendronate sodium Property

Melting point 245°C
storage temp. -20°C
solubility water, double-distilled: 10 mg/mL
form solid
color white
Water Solubility Soluble in water at 10mg/ml
Merck 14,229
Stability Store in freezer
InChIKey NKENDYHBVCKCNL-UHFFFAOYSA-M
CAS DataBase Reference 121268-17-5(CAS DataBase Reference)
NCI Dictionary of Cancer Terms alendronate sodium; Fosamax
FDA UNII 2UY4M2U3RA
NCI Drug Dictionary alendronate sodium
UNSPSC Code 41116107
NACRES NA.77

Safety

Hazard Codes :Xn,Xi
Risk Statements :22-36/37/38
Safety Statements :26-36-60
WGK Germany :3
RTECS :SZ6523500
HS Code :29310095

NFPA 704:

	0
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302
Precautionary statements P301+P312+P330

Alendronate sodium Price More Price(9)

Brand: Sigma-Aldrich(India)
Product number: PHR1599
Product name : Alendronate Sodium
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1G
Price: ₹11885.85
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: A4978
Product name : Alendronate sodium trihydrate
Purity: ≥97% (NMR), powder
Packaging: 100MG
Price: ₹25146.48
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 126855
Product name : Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem
Purity: An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.
Packaging: 100MG
Price: ₹24700
Updated: 2022/06/14
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Brand: TCI Chemicals (India)
Product number: A2456
Product name : Alendronate Sodium Trihydrate
Purity:
Packaging: 5G
Price: ₹5900
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A2456
Product name : Alendronate Sodium Trihydrate
Purity:
Packaging: 25G
Price: ₹9800
Updated: 2022/05/26
Buy: Buy

Alendronate sodium Chemical Properties,Usage,Production

Chemical Properties White Crystalline Solid
Originator Adronat ,Neopharmed ,Italy
Uses Alendronate sodium trihydrate is used as a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor. A robust inhibitor of bone resorption that induces apoptosis. Alendronate inhibits the migration and invasion of PC-3 cells (sc-2220) by interfering with the mevalonate pathway. Additionally, Alendronate, Sodium Salt is an inhibitor of CD45RC and MMP.
Uses Inhibits bone resorption and increases bone density.
Uses dopamine receptor agonist, antiParkinsonian
Uses A bisphosphonate used as a bone reabsoption inhibitor
Definition ChEBI: A hydride that is the trihydrate of alendronate sodium
Manufacturing Process 4-Amino-1-hydroxybutylidene-1,1-diphosphonic acid (ABDT).
Orthosphophorous acid (102.7 g; 1.25 moles) is introduced into a 2 liter-flask with condenser, stirrer and dropping funnel, placed on a thermostatized bath; the air is then removed with a nitrogen stream which is continued during all the reaction. The acid is melted by heating the bath to 95°C. When melting is complete, 4-aminobutyric acid (103.3; 1 mole) is added under stirring which is continued till obtaining a doughy fluid. Phosphorous trihalide (176 ml; 2 moles) is added dropwise causing the mixture to boil and evolution of gaseous hydrochloric acid which is damped by means of a suitable trap. The addition rate is adjusted so as to keep a constant reflux for about 60 minutes. When the addition is nearly over, the mixture swells, slowly hardening. Stirring is continued as long as possible, whereafter the mixture is heated for further 3 hours. Without cooling, but removing the bath, water (300 ml) is added, first slowly and then quickly. Heating and stirring are started again. Decolorizing charcoal is added and the mixture is boiled for about 5 minutes, then hotfiltered on paper and the filtrate is refluxed for 6 hours. After cooling is slowly poured in stirred methanol (1500 ml) causing thereby the separation of a white solid which collected and dried (161 g; 64.6%). The structure of ABDT is confirmed by IR spectrum, proton magnetic and nuclear magnetic resonance spectrum and elemental analysis.
The sodium salt of this acid may be prepared by adding of equivalent of sodium hydroxide.
brand name Fosamax (Merck).
Therapeutic Function Antiosteoporotic
General Description Alendronate Sodium, an aminobisphosphonate compound, has been effectively used for the treatment of osteolysis, Paget′s disease and osteoporosis.
Biochem/physiol Actions Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC50 = 460 nM); CD45 protein tyrosine phosphatase inhibitor.