Description
15(R)-Pinane thromboxane A
2 is the (R)-epimer of pinane thromboxane A
2 (PTA
2; ). 15(R)-PTA
2 does not inhibit collagen-induced platelet aggregation (IC
50s = 120-130 μM).
1 It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA
2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle.
2
Uses
15(R)-PTA2 (15(R)-Pinanethromboxane A2) is an antithrombotic agent that inhibits platelet aggregation. 15(R)-PTA2 inhibits stable prostaglandin endoperoxide analog-induced constriction of feline coronary arteries and stabilizes hepatic lysosomes. 15(R)-PTA2 also inhibits thromboxane synthase but has no effect on prostacyclin synthase[1].
References
1. Caton, M.P.L., Stuttle, K.A.J., Tuffin, D.P., et al.
Comparative action of carbocyclic thromboxane A2 stereoisomers on platelets Eur. J. Med. Chem. 35(12),1099-1107(2000).
2. Bennett, A., and Sanger, G.J.
Pinane thromboxane A2 analogues are non-selective prostanoid antagonists in rat and human stomach muscle Br. J. Pharmacol. 77(4),591-596(1982).
