71154-83-1

15(R)-Pinane thromboxane A₂ is the (R)-epimer of pinane thromboxane A₂ (PTA₂; ). 15(R)-PTA₂ does not inhibit collagen-induced platelet aggregation (IC₅₀s = 120-130 μM).¹ It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA₂ at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle.²

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1. Caton, M.P.L., Stuttle, K.A.J., Tuffin, D.P., et al. Comparative action of carbocyclic thromboxane A₂ stereoisomers on platelets Eur. J. Med. Chem. 35(12),1099-1107(2000).
2. Bennett, A., and Sanger, G.J. Pinane thromboxane A₂ analogues are non-selective prostanoid antagonists in rat and human stomach muscle Br. J. Pharmacol. 77(4),591-596(1982).