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nitroflurbiprofen

nitroflurbiprofen Structure
nitroflurbiprofen
  • CAS No.158836-71-6
  • Chemical Name:nitroflurbiprofen
  • CBNumber:CB21392461
  • Molecular Formula:C19H20FNO5
  • Formula Weight:361.36
  • MOL File:158836-71-6.mol
nitroflurbiprofen Property
  • Boiling point 468.8±45.0 °C(Predicted)
  • Density 1.214±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility Soluble in DMSO
  • form Oil
  • color Colorless to light yellow
  • FDA UNII Q8ERI3E76F
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

nitroflurbiprofen Chemical Properties,Usage,Production

  • Uses Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.
  • Definition ChEBI: A carboxylic ester obtained by formal condensation of the carboxy group of flurbiprofen with the free hydroxy group of 4-(nitrooxy)butanol. It is a non-steroidal anti-inflammatory agent showing inhibitory effects against the cyclooxygenases COX1 and COX2.
  • in vivo

    In vivo hemodynamic measurements (n = 8/condition) and evaluation of the increased intrahepatic resistance by in situ perfusion (n=5/condition) are performed in rats with thioacetamide-induced cirrhosis that receive either Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle by intraperitoneal injection 24 hours and 1 hour prior to the measurements. Treatment with Nitroflurbiprofen, an NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors[1].

  • IC 50 COX
  • References [1] Laleman W, et al. Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portalhypertension in rats. Gastroenterology. 2007 Feb;132(2):709-19. DOI:10.1053/j.gastro.2006.12.041
nitroflurbiprofen Preparation Products And Raw materials
Raw materials
Preparation Products
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nitroflurbiprofen Spectrum
158836-71-6, nitroflurbiprofenRelated Search:
  • 抑制剂
  • C19H20FNO5
  • 硝基氟比洛芬,10 MM DMSO 溶液
  • 硝基氟比洛芬(氟比洛芬杂质31)
  • 化合物 T16329
  • 硝基氟比洛芬
  • 158836-71-6
  • Nitroflurbiprofen, 10 mM in DMSO
  • Cyclooxygenase,Inhibitor,COX,Nitroflurbiprofen,HCT-1206,inhibit,HCT1206
  • [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, 4-(nitrooxy)butyl ester
  • Nitroxybutyl flurbiprofen
  • HCT 1206
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