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satratoxin G

satratoxin G Structure
satratoxin G
  • CAS No.53126-63-9
  • Chemical Name:satratoxin G
  • CBNumber:CB21391479
  • Molecular Formula:C29H36O10
  • Formula Weight:544.59
  • MOL File:53126-63-9.mol
satratoxin G Property
  • storage temp. Store at -20°C
  • solubility Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble
  • form A crystalline solid
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302+H312+H332
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P321-P330-P362+P364-P501

satratoxin G Chemical Properties,Usage,Production

  • Uses Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase [1][2].
  • Biological Activity Satratoxin G is a macrocyclic trichothecene mycotoxin that has been found in S. chartarum.1,2 It induces cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP) in HL-60 cells when used at a concentration of 40 nM and is cytotoxic to HepG2, Hep-2, Caco-2, A204, U937, and Jurkat cells (IC50s = 2.2-9.7 ng/ml).3,4 Intranasal administration of satratoxin G (500 μg/kg) induces apoptosis of olfactory sensory neurons in olfactory epithelium and ethmoid turbinate expression of the genes encoding IL-1α, IL-1β, IL-6, TNF-α, and MIP-2 in mice.2 Satratoxin G induces lethality in 4 week-old male mice (LD50 = 1.23 mg/kg, i.p.).1
  • in vivo

    Satratoxin G (500 μg/kg, intranasal instillation) can induce the apoptosis of olfactory sensory neurons in mouse olfactory epithelium, and express IL-1α, IL-1β, IL-6, TNF-α and MIP-2 genes[2].

    Animal Model:Pathogen-free female C57Bl/6 mice [2]
    Dosage:500 μg/kg
    Administration:intranasal instillation
    Result:Up-regulated the proapoptotic genes Fas, FasL, p75NGFR, p53, Bax, caspase-3, and CAD.
    Increased expression of mRNAs for the cytokines TNF-α, IL-1α, IL-1β, and IL-6 as well as the chemokine MIP-2.
  • References |1. Yoshizawa, T., Ohtsubo, K., Sasaki, T., et al. Acute toxicities of satratoxins G and H in mice--a histopathological observation with special reference to the liver injury caused by satratoxin G. Proc. Jpn. Assoc. Mycotoxicol. 23, 53-57 (1986).|2. Islam, Z., Harkema, J.R., and Pestka, J.J. Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain. Environ. Health Perspect. 114(7), 1099-1107 (2006).|3. Nagase, M., Shiota, T., Tsushima, A., et al. Molecular mechanism of satratoxin-induced apoptosis in HL-60 cells: Activation of caspase-8 and caspase-9 is involved in activation of caspase-3. Immunol. Lett. 84(1), 23-27 (2002).|4. Nielsen, C., Casteel, M., Didier, A., et al. Trichothecene-induced cytotoxicity on human cell lines. Mycotoxin Res. 25(2), 77-84 (2009).
satratoxin G Preparation Products And Raw materials
Raw materials
Preparation Products
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satratoxin G Spectrum
53126-63-9, satratoxin GRelated Search:
  • 抑制剂
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  • 53126-63-9
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