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Dantrolene sodium salt

Dantrolene sodium salt Structure
Dantrolene sodium salt
  • CAS No.14663-23-1
  • Chemical Name:Dantrolene sodium salt
  • CBNumber:CB2128232
  • Molecular Formula:C14H11N4NaO5
  • Formula Weight:338.25
  • MOL File:14663-23-1.mol
Dantrolene sodium salt Property
  • storage temp. Store at RT
  • solubility Soluble in DMSO (up to 3 mg/ml)
  • form Orange solid
  • color Orange
  • Merck 14,2816
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF/ethanol may be stored at -20°C for up to 1 month.
  • InChIKey KSRLIXGNPXAZHD-HAZZGOGXSA-M
  • CAS DataBase Reference 14663-23-1(CAS DataBase Reference)
  • FDA UNII 28F0G1E0VF
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :2
  • RTECS  :MU3875000
  • HS Code  :2942.00.3500
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319
  • Precautionary statements P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Dantrolene sodium salt Price More Price(6)
  • Brand: Sigma-Aldrich(India)
  • Product number: D9175
  • Product name : Dantrolene sodium salt
  • Purity: 
  • Packaging: 100MG
  • Price: ₹10716.75
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D9175
  • Product name : Dantrolene sodium salt
  • Purity: 
  • Packaging: 250MG
  • Price: ₹22245.38
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D9175
  • Product name : Dantrolene sodium salt
  • Purity: 
  • Packaging: 1G
  • Price: ₹61518.48
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 251680
  • Product name : Dantrolene, Sodium Salt - CAS 14663-23-1 - Calbiochem
  • Purity: A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor.
  • Packaging: 100MG
  • Price: ₹8210
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D3996
  • Product name : Dantrolene Sodium Salt Hydrate
  • Purity: 
  • Packaging: 1G
  • Price: ₹6400
  • Updated: 2022/05/26
  • Buy: Buy

Dantrolene sodium salt Chemical Properties,Usage,Production

  • Description Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50 = 0.3 μM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kd values of 0.3 and 0.09 μM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50 values of 0.42 and 0.19 μM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 μg/ml) and MHS pigs (ED50 = 0.85 mg/kg). Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.
  • Chemical Properties mp 279-280C 3415821
  • Uses Skeletal muscle relaxant;Blocker of Ca2+ release
  • Uses Dantrolene Sodium Salt is a skeletal muscle relaxant, which inhibits intracellular Ca 2+release from the sarcoplasmic reticulum.
  • Definition ChEBI: The anhydrous sodium salt of dantrolene.
  • brand name Dantrium (Procter & Gamble).
  • Biological Activity Inhibits release of Ca 2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.
  • storage Store at RT
  • References 1) Zhao?et al.?(2001),?Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity; J. Biol. Chem.,?276?13810 2) Frandsen and Schousboe (1992),?Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainite in cultured cerebral cortical neurons; Proc. Natl. Acad. Sci. USA,?89?2590 3) Muehlschlegel and Sims (2009),?Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit; Neuro. Crit. Care,?10?103 4) Lu?et al.?(2014),?A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome; Proc. Natl. Acad. Sci. USA,?111?E5292
Dantrolene sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
Dantrolene sodium salt Suppliers
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Dantrolene sodium salt Spectrum
14663-23-1, Dantrolene sodium saltRelated Search:
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  • Inhibitor of Ca2+ release from sarcoplasmic reticulum; muscle relaxant.
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