Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH2

Uses

GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2].

IC 50

NK2

References

[1] Saffroy M, et, al. Presence of NK2 binding sites in the rat brain. J Neurochem. 2001 Dec;79(5):985-96. DOI:10.1046/j.1471-4159.2001.00633.x
[2] Palea S, et, al. Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate. J Pharmacol Exp Ther. 1996 May;277(2):700-5. PMID:8627548