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Beclamide

Beclamide Structure
Beclamide
  • CAS No.501-68-8
  • Chemical Name:Beclamide
  • CBNumber:CB1875348
  • Molecular Formula:C10H12ClNO
  • Formula Weight:197.66
  • MOL File:501-68-8.mol
Beclamide Property
  • Melting point 94°
  • Boiling point 386.9±35.0 °C(Predicted)
  • Density 1.1363 (rough estimate)
  • refractive index 1.5330 (estimate)
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • solubility Chloroform (Slightly), Methanol (Slightly)
  • form Solid
  • pka 15.55±0.46(Predicted)
  • color Large crystals from MeOH
  • FDA UNII F5N0ALI65V
  • ATC code N03AX30
Safety
  • HS Code  :2924297099
  • Toxicity :LD50 orl-rat: 3200 mg/kg JPETAB 107,403,53
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H335-H315-H318
  • Precautionary statements P264-P280-P302+P352-P321-P332+P313-P362-P280-P305+P351+P338-P310

Beclamide Chemical Properties,Usage,Production

  • Originator Posedrine,Biosa,Switz.
  • Uses anticonvulsant, antiepileptic
  • Uses Beclamide is a chlorinated benzylpropanamide used as an anticonvulsant drug. It is used in the treatment of tonic-clonic seizyres and has sedative properties.
  • Definition ChEBI: Beclamide is a member of benzenes.
  • Manufacturing Process A 100 gallon lined jacketed kettle provided with cooling is charged with 100 lb of benzylamine and 150 liters of water. The mixture is cooled to 5°C and with stirring 119 lb of β-chloropropionyl chloride and a solution of 45 lb of sodium hydroxide pellets in 40 liters of water are added simultaneously at such a rate that the temperature does not exceed 10°C. During this period the pH of the mixture should be on the alkaline side but below pH 9.5. When the addition is complete the pH should be about 8. The mixture is stirred overnight in the cold, and the solid product is filtered. The filter cake is reslurred with about 80 gallons of water, filtered, and air-dried. Yield, 128 pounds.
    The crude material is recrystallized by dissolving it in the minimal quantity of hot methanol (about 50 gallons), adding Norite, and filtering hot. Upon cooling slowly (finally to about 5°C) large crystals separate: they are filtered and air-dried. Yield, 109 pounds. Melting point 92° to 93°C.
  • Therapeutic Function Anticonvulsant
  • Safety Profile Moderately toxic by ingestion,intraperitoneal and intravenous routes. When heated todecomposition it emits very toxic fumes of Cl- and NOx.An anticonvulsant.
Beclamide Preparation Products And Raw materials
Raw materials
Preparation Products
Beclamide Suppliers
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Beclamide Spectrum
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