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GUANIDINOETHYL SULFONATE

GUANIDINOETHYL SULFONATE Structure
GUANIDINOETHYL SULFONATE
  • CAS No.543-18-0
  • Chemical Name:GUANIDINOETHYL SULFONATE
  • CBNumber:CB1741690
  • Molecular Formula:C3H9N3O3S
  • Formula Weight:167.19
  • MOL File:543-18-0.mol
GUANIDINOETHYL SULFONATE Property
  • Melting point 263-265°C
  • Density 1.73±0.1 g/cm3(Predicted)
  • storage temp. Refrigerator
  • solubility DMSO (Very Slightly, Heated), Methanol (Very Slightly, Heated), Water (Heated)
  • pka 1.31±0.50(Predicted)
  • form Solid
  • color White to Off-White
  • CAS DataBase Reference 543-18-0
  • UNSPSC Code 12352106
Safety
  • Risk Statements  :34
  • Safety Statements  :26-36/37/39
  • RIDADR  :3261
  • HS Code  :2927000090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

GUANIDINOETHYL SULFONATE Chemical Properties,Usage,Production

  • Description Guanidinoethyl sulfonate, also known as taurocyamine, is a natural guanidine-taurine analog derived from taurine. It is an intermediate of taurine and hypotaurine metabolism and is phosphorylated by taurocyamine kinase. Guanidinoethyl sulfonate competitively inhibits taurine uptake by sodium-dependent taurine transporters in rat hepatocytes (Ki = 1.75 mM). It also acts as a competitive glycine receptor antagonist in mouse striatal neurons. Plasma levels of guanidinoethyl sulfonate are significantly increased in patients with chronic renal failure.
  • Chemical Properties White Solid
  • Uses A potent inhibitor of taurine transport.
  • Definition ChEBI: Zwitterionic form of taurocyamine arising from transfer of a proton from the sulfo to the guanidino group; major species at pH 7.3.
  • in vitro guanidinoethyl sulphonate was found to be an analogue of taurine and an inhibitor of taurine transport. guanidinoethyl sulphonate was also shown to be a weak agonist at gaba(a) receptors, and was able to antagonize gaba-evoked responses. guanidinoethyl sulphonate did not gate glyr. 3. but antagonized glycine responses in a concentration-dependent and surmountable manner. glycine receptor-mediated taurine responses were competitively antagonized by guanidinoethyl sulphonate. taurine dose-response curves, in contrast to the glycine dose-response curves were shifted by guanidinoethyl sulphonate to the right in a parallel manner [1].
  • in vivo guanidinoethyl sulphonate delivered in the drinking water of rats for 1 month could effectively reduce taurine levels in brain structures and outside the brain by between 50 and 80 %, depending on the tissue. this partial taurine depletion could not affect either basal synaptic transmission or the late phase of long-term potentiation in hippocampal slices. in-vivo microdialysis studies in the hippocampus demonstrated that guanidinoethyl sulphonate was able to reduce extracellular taurine levels and the magnitude of taurine released in response to the application of either n-methyl-d-aspartate or a hypoosmotic solution [2].
  • References [1] sergeeva, o. a.,chepkova, a.n., and hass, h.l. guanidinoethyl sulphonate is a glycine receptor antagonist in striatum. british journal of pharmacology 137, 855-860 (2002).
    [2] suárez lm, muoz md, gonzález jc, bustamante j, del río rm, solís jm. the taurine transporter substrate guanidinoethyl sulfonate mimics the action of taurine on long-term synaptic potentiation. amino acids. 2016 nov;48(11):2647-2656. epub 2016 jul 15.
GUANIDINOETHYL SULFONATE Preparation Products And Raw materials
Raw materials
Preparation Products
GUANIDINOETHYL SULFONATE Suppliers
Global(81)Suppliers
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GUANIDINOETHYL SULFONATE Spectrum
543-18-0, GUANIDINOETHYL SULFONATERelated Search:
  • Sulfur & Selenium Compounds
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Inhibitors
  • All Inhibitors
  • 抑制剂
  • 高端化学
  • 化工原材料
  • C3H9N3O3S
  • 胍基磺酸乙酯
  • 3-GUANIDINOETHANESULFONIC ACID
  • 脒基牛磺酸 标准品
  • 二胍基乙烷磺酸
  • 脒基牛磺酸
  • 543-18-0
  • Guanidinoethyl sulfonate,Endogenous Metabolite,inhibit,Inhibitor,taurine transport antagonist
  • TAUROCYAMINE
  • SKL456
  • Ethanesulfonic acid,2-[(aminoiminomethyl)amino]-
  • taurocyamine zwitterion
  • Taurocyamin
  • NSC 667063
  • N-Guanyltaurine
  • Guanidinoethanesulfonic Acid
  • Amidinotaurine
  • 2-Guanylaminoethanesulfonic Acid
  • 2-[(Aminoiminomethyl)amino]thanesulfonic Acid
  • 2-(diaminomethylideneamino)ethanesulfonic acid
  • N-Amidinotaurine
  • 2-{[amino(imino)methyl]amino}ethane-1-sulphonic acid
  • GUANIDINOETHYL SULFONATE
  • 2-([AMINO(IMINO)METHYL]AMINO)ETHANE-1-SULFONIC ACID
  • 2-GUANIDINOETHANE SULFONIC ACID

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