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NAPHTHOFLUORESCEIN

CAS No.61419-02-1
Chemical Name:NAPHTHOFLUORESCEIN
CBNumber:CB1689770
Molecular Formula:C28H16O5
Formula Weight:432.42
MOL File:61419-02-1.mol

NAPHTHOFLUORESCEIN Property

Melting point 189 °C (dec.)(lit.)
Boiling point 755.5±60.0 °C(Predicted)
Density 1.58±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: soluble
form A crystalline solid
pka 8.82±0.20(Predicted)
color Purple to purplish red
BRN 61335
InChIKey IXQIUDNVFVTQLJ-UHFFFAOYSA-N
EPA Substance Registry System Spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one, 3,11-dihydroxy- (61419-02-1)
UNSPSC Code 12352108
NACRES NA.32

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36
WGK Germany :3
F :8-10
HS Code :29329990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338

NAPHTHOFLUORESCEIN Price More Price(2)

Brand: Sigma-Aldrich(India)
Product number: 70420
Product name : Naphthofluorescein
Purity: suitable for fluorescence
Packaging: 100MG
Price: ₹5239.2
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 70420
Product name : Naphthofluorescein
Purity: suitable for fluorescence
Packaging: 500MG
Price: ₹21489.6
Updated: 2022/06/14
Buy: Buy

NAPHTHOFLUORESCEIN Chemical Properties,Usage,Production

Uses Naphthofluorescein is a furin inhibitor.
Uses Naphtofluorescein is a pH-sensitive fluorescent probe, also used for preparation of labels and enzyme substrates.
Definition ChEBI: Naphthofluorescein is a member of xanthenes.

in vivo

Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks)does not show weight loss or apparent histological abnormalities in the lung, liver, and kidney, or cause cause severe adverse effects for at least 2 weeks in mice^[1].
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks) strikingly suppresses the tumour growth of subcutaneously injected E0771 cells and significantly attenuates tumour growth of MDA-MB-231 and AsPC-1 cells in immunodeficient mice. In turn, naphthofluorescein does not attenuate tumour growth of FIH-1-depleted MDA-MB-231 cells^[1].
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks) suppresses tumour growth in human cancer cells in an FIH-1-dependent manner^[1].

Animal Model:	Male C57BL/6J mice (8 weeks)^[1]
Dosage:	100 mg/kg
Administration:	i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks
Result:	Neither showed weight loss or apparent histological abnormalities in the lung, liver, and kidney, or caused cause severe adverse effects for at least 2 weeks in mice.

Animal Model:	Female C57BL/6J mice (E0771) and BALB/c nude mice (HT1080, MDA-MB-231, and AsPC-1) (6 weeks)^[1]
Dosage:	100 mg/kg
Administration:	i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks
Result:	Strikingly suppressed the tumour growth of subcutaneously injected E0771 cells and significantly attenuated tumour growth of MDA-MB-231 and AsPC-1 cells in immunodeficient mice. In turn, naphthofluorescein did not attenuate tumour growth of FIH-1-depleted MDA-MB-231 cells.

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