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Rauwolscine hydrochloride

Rauwolscine hydrochloride Structure
Rauwolscine hydrochloride
  • CAS No.6211-32-1
  • Chemical Name:Rauwolscine hydrochloride
  • CBNumber:CB1684795
  • Molecular Formula:C21H27ClN2O3
  • Formula Weight:390.9
  • MOL File:6211-32-1.mol
Rauwolscine hydrochloride Property
  • Melting point 270-280°C
  • storage temp. Store at RT
  • solubility H2O: soluble
  • form solid
  • color white
  • Sensitive Light Sensitive
  • FDA UNII PQ323MIB24
Safety
  • Hazard Codes  :T
  • Risk Statements  :23/24/25
  • Safety Statements  :22-36/37/39-45
  • RIDADR  :UN 1544 6.1/PG 2
  • WGK Germany  :3
  • RTECS  :ZG1035000
  • HazardClass  :6.1
  • HS Code  :29339900
  • NFPA 704:
    0
    4 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H300-H310-H330
  • Precautionary statements P301+P310a-P304+P340-P320-P330-P405-P501a

Rauwolscine hydrochloride Chemical Properties,Usage,Production

  • Description This alkaloid is isolated as the oxalate from the leaf extract of Rauwolfia canescens L. from which the free base may be obtained as colourless needles which are laevorotatory with [α]30D - 40° (EtOH). The alkaloid forms crystalline salts: the hydrochloride, m.p. 27S-2S00C (dec.); [α]30D + 74° (H20); nitrate, m.p. 257-SoC (dec.); oxalate, m.p. 245-6°C and the picrate, m.p. 20SoC. Two active hydrogens are present and the alkaloid furnishes a monoacetyl derivative, m.p. 2l6-SoC (dec.). Treatment with concentrated ammonia solution at room temperature converts the base into rauwolscinic acid, C2oH2403N2.H20, m.p. 262-4°C (dec.); [α]23D + l36.So (H20) which yields a crystalline hydrochloride, m.p. 255.5-257.5°C (dec.) and on esterification with MeOH reverts to the original alkaloid. On distillation with Zn dust, rauwolscine yields harman, 2-methylindole (skatole) and isoquinoline.
    Chakravarti has shown that the alkaloid is a cardiovascular depressant, shows hypotensive activity and is relatively highly toxic.
  • Uses Standard alpha-2 adrenergic antagonist
  • Uses Rauwolscine is a natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM). It is a stereoisomer of yohimbine, which potently antagonizes both α1- and α2-adrenergic receptors. Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki = 14.3 nM) and as a weak partial agonist at 5-HT1A (IC50 = 1.3 μM).The α2-adrenergic receptor has diverse physiological functions and antagonists like rauwolscine have numerous applications, including the modulation of mood and behavior.
  • Biological Activity Rauwolscine hydrochloride is a standard α2-adrenergic antagonist (Ki values are 3.5, 4.6, and 0.6 nM at cloned human α2A, α2B, and α2C-adrenoceptors respectively). Partial agonist at 5-HT1A receptors. Also available as part of the α2-Adrenoceptor Tocriset? .
  • References Mukherjee., J. Ind. Chern. Soc., 18, 33, 485 (1941)
    Mukherjee., ibid, 20, 11 (1943)
    Mukherjee., ibid, 23, 6 (1946)
    Pharmacology:
    Chakravarti., Sci. Cult., (Calcutta), 7, 45S (1942)
Rauwolscine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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Rauwolscine hydrochloride Spectrum
6211-32-1, Rauwolscine hydrochlorideRelated Search:
  • Adrenoceptor
  • 抑制剂
  • 药靶配体
  • 原料
  • 植物提取物
  • 萝芙素盐酸盐,10 MM DMSO 溶液
  • RAUWOLSCINE HYDROCHLORIDE,ALPHA2 ADRENERGIC拮抗剂
  • RAUWOLSCINE盐酸盐
  • 盐酸劳沃斯辛
  • 育亨宾盐酸盐, 来源于育亨宾
  • 育亨宾提取物 育亨宾碱
  • 萝芙素盐酸盐(甄准不供应)
  • 萝芙素
  • 育亨宾碱
  • 萝芙素盐酸盐
  • ALPHA-盐酸育亨宾
  • 洛芙素盐酸盐
  • 6211-32-1
  • Rauwolscine hydrochloride, 10 mM in DMSO
  • Rauwolscine hydrochloride, alpha2 adrenergic antagonist
  • Rauwolscine hydrochloride,α-Yohimbine,Corynanthidine,Rauwolscine,Adrenergic Receptor,Inhibitor,Beta Receptor,inhibit,Isoyohimbine
  • RAUWOLSCINE HCL
  • RAUWOLSCINE
  • α-Yohimbine hydrochloride
  • Rauwolscine Hydrochloride,Rauwolscine
  • Rauwolscine hydrochloride, 98%, from Yohimbe
  • ALPHA YOHIMBINE HCL 90% (Rauwolscine HCL 90%)
  • Rauwolscine dot hydrochloride
  • Isoyohimbine hydrochloride
  • Corynanthidine hydrochloride
  • 17A-HYDROXY-20A-YOHIMBAN-16B-CARBOXYLIC ACID,METHYL ESTER HYDROCHLORIDE
  • 17ALPHA-HYDROXY-20ALPHA-YOHIMBAN-16 BETA-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
  • methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate hydrochloride
  • ALPHA-YOHIMBINE HYDROCHLORIDE
  • ALPHA-YOHIMBINE HCL
  • ALPHA-YOHIMBINE
  • 17α-Hydroxy-20α-yohimban-16β-carboxylicacid,methylesterhydrochloride
  • Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, monohydrochloride, (16.beta.,17.alpha.,20.alpha.)-
  • Nsc407307
  • Fauwolscine, hydrochloride
  • 20.alpha.-Yohimban-16.beta.-carboxylic acid, 17.alpha.-hydroxy-, methyl ester, monohydrochloride
  • MESOYOHIMBINE
  • ISOYOHIMBINE
  • RAUWOLSCINE HYDROCHLORIDE
  • RAUWOLFSCINE HYDROCHLORIDE
  • alpha-yohimbinhydrochloride
  • 20-alpha-yohimban-16-beta-carboxylicacid,17-alpha-hydroxy-,methylester,hyd
  • YOHIMBINE HCL, ALPHA-
  • YohiMban-16-carboxylicacid, 17-hydroxy-, Methyl ester, hydrochloride (1:1), (16b,17a,20a)-
  • α-Yohimbine hydrochloride, 17α-Hydroxy-20α-yohimban-16 β-carboxylic acid methyl ester hydrochloride
  • RAUWOLSCINE HYDROCHLORIDE (A-YOHIMBINE) A2 AD

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