A-18-F-NH2
- Product NameA-18-F-NH2
- CAS99588-52-0
- CBNumberCB1682771
- MFC89H130N24O24
- MW1920.13
- MDL NumberMFCD00076703
- MOL File99588-52-0.mol
Chemical Properties
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | -15°C |
| pka | 4.43±0.10(Predicted) |
A-18-F-NH2 Chemical Properties,Usage,Production
Uses
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects[1][2].in vivo
Neuropeptide AF (cattle) (0.25 μg/2 μL; i.c.v.; 30 min prior to the tests) decreases the immobility time and increases the climbing and swimming times in modified mouse forced swimming test (mFST)[2].
| Animal Model: | Male CFLP mice (25-28 g)[2] |
| Dosage: | 0.25 μg/2 μL |
| Administration: | i.c.v.; 30 min prior to the tests |
| Result: | Decreased the immobility time and increased the climbing and swimming times. |
References
[1] Nada Abdellah, et al. Neuropeptide AF Induces Piecemeal Degranulation in Murine Mucosal Mast Cells: A New Mediator in Neuro-Immune Communication in the Intestinal Lamina Propria Anat Rec (Hoboken). 2018 Jun;301(6):1103-1114. DOI:10.1002/ar.23780[2] Miklós Palotai, et al. Neuropeptide AF induces anxiety-like and antidepressant-like behavior in mice. Behav Brain Res. 2014 Nov 1;274:264-9. DOI:10.1016/j.bbr.2014.08.007
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