Description
3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) is an intermediate in several metabolic pathways.1,2,3,4 Conversion of HMG-CoA to mevalonate by HMG-CoA reductase is the rate-limiting first step in the cholesterol biosynthetic pathway.2,3 Alternatively, HMG-CoA can be cleaved into acetyl-CoA and the ketone body acetoacetate in mitochondria by HMG-CoA lyase.1,4 HMG-CoA is also an intermediate in the degradation of leucine.4WARNING This product is not for human or veterinary use.
References
[1] LAFFEL L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes[J]. Diabetes/Metabolism Research and Reviews, 2000, 15 6: 412-426. DOI:
10.1002/(sici)1520-7560(199911/12)15:6<412::aid-dmrr72>3.0.co;2-8[2] PETER J ESPENSHADE Adam L H. Regulation of sterol synthesis in eukaryotes.[J]. Annual review of genetics, 2007, 41: 401-427. DOI:
10.1146/annurev.genet.41.110306.130315[3] AKIRA HONDA 385 TREMONT AVE. Regulation of early cholesterol biosynthesis in rat liver: Effects of sterols, bile acids, lovastatin, and BM 15.766 on 3-hydroxy-3-methylglutaryl coenzyme A synthase and acetoacetyl coenzyme A thiolase activities[J]. Hepatology, 2003, 27 1: 154-159. DOI:
10.1002/hep.510270124[4] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
