Description
Octanoyl-coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye’s syndrome and β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH) is decreased in patients with MCADH deficiency (MCD). Octanoyl-CoA inhibits citrate synthase and glutamate dehydrogenase.
References
[1] J C LAI. Differential effects of fatty acyl coenzyme A derivatives on citrate synthase and glutamate dehydrogenase.[J]. Research communications in chemical pathology and pharmacology, 1993, 82 3: 331-338.
[2] B E CORKEY. Relationship between unusual hepatic acyl coenzyme A profiles and the pathogenesis of Reye syndrome.[J]. Journal of Clinical Investigation, 1988, 82 3: 782-788. DOI:
10.1172/jci113679[3] B A AMENDT W J R. Catalytic defect of medium-chain acyl-coenzyme A dehydrogenase deficiency. Lack of both cofactor responsiveness and biochemical heterogeneity in eight patients.[J]. Journal of Clinical Investigation, 1985, 76 3: 963-969. DOI:
10.1172/jci112096
