ChemicalBook > CAS DataBase List > CLORGYLINE HYDROCHLORIDE

CLORGYLINE HYDROCHLORIDE

CLORGYLINE HYDROCHLORIDE Structure
CLORGYLINE HYDROCHLORIDE
  • CAS No.17780-75-5
  • Chemical Name:CLORGYLINE HYDROCHLORIDE
  • CBNumber:CB1445257
  • Molecular Formula:C13H16Cl3NO
  • Formula Weight:308.63
  • MOL File:17780-75-5.mol
CLORGYLINE HYDROCHLORIDE Property
  • storage temp. 2-8°C
  • solubility ≥17.65 mg/mL in DMSO; ≥18.2 mg/mL in EtOH; ≥24.8 mg/mL in H2O
  • form A crystalline solid
  • color White to off-white
  • FDA UNII H38V165133
  • UNSPSC Code 12352116
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :20/21/22
  • Safety Statements  :36
  • RIDADR  :UN 2811 6.1/PG 3
  • WGK Germany  :3
  • RTECS  :UI0675000
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • NFPA 704:
    0
    3 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301-H312+H332
  • Precautionary statements P261-P264-P280-P301+P310-P302+P352+P312-P304+P340+P312
CLORGYLINE HYDROCHLORIDE Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: M3778
  • Product name : N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride
  • Purity: ≥97% (GC)
  • Packaging: 50MG
  • Price: ₹9677.55
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: M3778
  • Product name : N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride
  • Purity: ≥97% (GC)
  • Packaging: 100MG
  • Price: ₹17265.88
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: M3778
  • Product name : N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride
  • Purity: ≥97% (GC)
  • Packaging: 500MG
  • Price: ₹67537.18
  • Updated: 2022/06/14
  • Buy: Buy

CLORGYLINE HYDROCHLORIDE Chemical Properties,Usage,Production

  • Description Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 μM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin receptors, but it does inhibit the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM). As MAO-A preferentially oxidizes serotonin, selective MAO-A inhibitors have applications in ameliorating depression and anxiety.
  • Uses Antidepressant;Monoamine oxidase A inhibitor
  • Uses N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride has been used as a monoamine oxidase A (MAO-A) inhibitor:
    • in MAO-A biochemical assay
    • to study its effects on the transit of serotonin (5-HT) in the human placenta explants
    • to study its effects on human prostate cancer cells

  • Biochem/physiol Actions MAO-A inhibitor.
  • in vivo

    Clorgyline hydrochloride (2 mg/kg, infuse, daily for 28 days) increases Nicotine infusions and shows an increased level of motivation to obtain Nicotine similarly in low responder and high responder rats than vehicle-treated rats[2].
    Clorgyline hydrochloride (1mg/kg, i.v., pretreated for 1 h) pretreatment has little effect on the efflux of conjugated dopamine (DA) and p-tyramine-evoked release of conjugated DA from slices of rat striatum[3].

  • References [1]. abdelhafez om, amin km, ali hi, et al. synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase a inhibitors. j med chem. 2012 dec 13;55(23):10424-36.
    [2]. mazouz f, gueddari s, burstein c, et al. 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3h)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type b inhibitors. j med chem. 1993 apr 30;36(9):1157-67.
    [3]. garcia-miralles m, ooi j, ferrari bardile c, et al. treatment with the mao-a inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of huntington disease. exp neurol. 2016 apr;278:4-10.
CLORGYLINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
CLORGYLINE HYDROCHLORIDE Suppliers
Global(107)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Career Henan Chemica Co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：laboratory@coreychem.com
  • Country：China
  • ProdList：30231
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
  • Supplier：
    LEAPCHEM CO., LTD.
  • Tel：+86-852-30606658
  • Email：market18@leapchem.com
  • Country：China
  • ProdList：43340
  • Advantage：58
CLORGYLINE HYDROCHLORIDE Spectrum
17780-75-5, CLORGYLINE HYDROCHLORIDERelated Search:
  • 抑制剂
  • 生化试剂
  • 小分子抑制剂
  • BioChemical
  • Biochemicals and Reagents
  • Monoamine Oxidase-A
  • L to O
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors
  • C13H15Cl2NOHCl
  • 单氨氧化酶A重组兔单抗
  • 盐酸氯吉林,10 MM DMSO 溶液
  • CLORGYLINE HYDROCHLORIDE,MAO-A抑制剂
  • PERFEMIKER]N-[3-(2,4-二氯苯氧基)丙基]-N-甲基-2-丙炔胺盐酸盐,98%
  • N-(3-(2,4-二氯苯氧基)丙基)-N-甲基丙-2-炔-1-胺 盐酸盐
  • 氯吉兰盐酸盐 标准品
  • 盐酸氯吉林
  • N-甲基-N-炔丙基-3-(2,4-二氯苯氧基)丙胺盐酸盐
  • N - [3 - (2,4 -二氯苯氧基)丙基] - N -甲基- 2 -丙炔胺盐酸盐
  • N-甲基-N-丙炔基-3-(2,4-二氯苯氧基)丙胺盐酸盐
  • N-甲基-N-炔丙基-3-(2,4- 二氯苯氧基)丙基胺
  • 17780-75-5
  • Clorgyline hydrochloride, 10 mM in DMSO
  • Clorgyline hydrochloride, MAO-A inhibitor
  • Clorgyline HCl (M&B 9302, MB9302)
  • N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride >=97% (GC)
  • N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine
  • N-(3-(2,4-dichlorophenoxy)propyl)-N-methylprop-2-yn-1-amine hydrochloride
  • Clorgyline HCl
  • Clorgiline (hydrochloride)
  • 3-(2,4-dichlorophenoxy)-n-Methyl-n-prop-2-ynylpropan-1-aMine hydrochloride
  • 2-Propyn-1-aMine, N-[3-(2,4-dichlorophenoxy)propyl]-N-Methyl-, hydrochloride
  • N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride,Clorgyline
  • N-METHYL-N-PROPARGYL-3-(2,4-*DICHLOROPHE NOXY)PROPYL
  • N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propynylamine hydrochloride
  • N-methyl-N-propargyl-3-(2,4-*dichlorophenoxy)prop
  • n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylaminhydrochloride
  • n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propyn-1-aminhydrochloride
  • 3-(2,4-dichlorophenoxy)-n-methyl-n-propargyl-propylaminhydrochloride
  • N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)-PROPYLAMINE HYDROCHLORIDE
  • CLORGYLINE HYDROCHLORIDE

Home

My