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Cinobufotalin

Cinobufotalin Structure
Cinobufotalin
  • CAS No.1108-68-5
  • Chemical Name:Cinobufotalin
  • CBNumber:CB1410581
  • Molecular Formula:C26H34O7
  • Formula Weight:458.54
  • MOL File:1108-68-5.mol
Cinobufotalin Property
  • Melting point 259-262°
  • alpha D20 +11°
  • Boiling point 627.3±55.0 °C(Predicted)
  • Density 1.34±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml
  • pka 14.67±0.70(Predicted)
  • form White to off-white solid.
  • color White to off-white
  • CAS DataBase Reference 1108-68-5
  • FDA UNII L0QBZ37386
  • NCI Drug Dictionary cinobufotalin
Safety
  • Hazard Codes  :T+
  • Risk Statements  :26/27/28
  • Safety Statements  :22-36/37/39-45
  • RIDADR  :UN 2811 6.1/PG 1
  • WGK Germany  :3
  • RTECS  :EI2991000
  • HazardClass  :6.1(a)
  • PackingGroup  :II
  • Toxicity :cat,LD50,intravenous,200ug/kg (0.2mg/kg),"Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963Vol. -, Pg. 189, 1963.
  • NFPA 704:
    0
    4 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300+H310+H330
  • Precautionary statements P260-P262-P264-P280-P302+P352+P310-P304+P340+P310

Cinobufotalin Chemical Properties,Usage,Production

  • Description Cinobufacin is an indole-type total alkaloid extracted from the dried toad skin of Chinese toad, which has the functions of clearing away heat and detoxifying, reducing swelling and pain, promoting blood circulation and removing blood stasis, softening and dispelling knots.
  • Uses Cinobufotalin is a cardiotonic steroids or bufadienolides, is extracted from the skin secretions of the giant toads. Cinobufotalin has been used as a cardiotonic, diuretic and a hemostatic agent, Cinobufotalin is also a potential anti-lung cancer agent[1].
  • Application Cinobufacin can be used for a variety of middle and advanced tumors (lung cancer, breast cancer, cervical cancer, digestive system tumors such as primary liver cancer, gastric cancer, colon cancer, etc.), chronic hepatitis B, especially for chronic hepatitis B virus carriers. Especially prominent.
  • Side effects For individual patients, if the dosage is too large or the interval between two administrations is less than 6 to 8 hours, chills and fever may occur about 30 minutes after administration; a small number of patients have local irritation or phlebitis after long-term intravenous infusion, which will slow down the infusion rate. Very few patients may also appear urticaria, dermatitis and so on.
  • in vivo

    Cinobufotalin (1-5 mg/kg; intraperitoneal injection; twice daily; for 1 weeks; male nude mice) treatment inhibits A549 lung cancer cell growth in vivo[1].

    Animal Model:Male nude mice (4-6 weeks old, BALB/c) with A549 cells[1]
    Dosage:1 mg/kg or 5 mg/kg
    Administration:Intraperitoneal injection; twice daily; for 1 weeks
    Result:Inhibited A549 lung cancer cell growth in vivo.
  • References [1] Kai S, et al. Pre-clinical evaluation of cinobufotalin as a potential anti-lung cancer agent. Biochem Biophys Res Commun. 2014 Sep 26;452(3):768-74. DOI:10.1016/j.bbrc.2014.08.147
    [2] Li C, Guo H, Wang C, et al. Network pharmacological mechanism of Cinobufotalin against glioma. Prog Brain Res. 2021;265:119-137. DOI:10.1016/bs.pbr.2021.06.001
Cinobufotalin Preparation Products And Raw materials
Raw materials
Preparation Products
Cinobufotalin Suppliers
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Cinobufotalin Spectrum
1108-68-5, CinobufotalinRelated Search:
  • 类固醇
  • 抑制剂
  • 标准品-中药标准品
  • 标准品 -中药标准品
  • 对照品-中药对照品
  • 标准品-对照品
  • 对照品
  • 植物提取物
  • 标准品
  • 中药对照品
  • C26H34O7
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  • 华蟾毒它灵 标准品
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  • 华蟾毒它灵(华蟾蜍素
  • 蟾素
  • 华蟾素, HPLC≥98%
  • 华蟾素\华蟾毒它灵
  • 华蟾毒它灵, 来源于动物提取物
  • 华蟾毒它灵
  • 华蟾蜍毒它灵
  • 华蟾蜍素
  • 华蟾素
  • 华蟾蜍它灵
  • 华蟾蜍素,华蟾蜍毒它灵、华蟾蜍它灵,华蟾素
  • 华蟾素(标准品)
  • 华蟾毒它灵(华蟾蜍素,华蟾蜍毒它灵、华蟾蜍它灵,华蟾素)
  • 1108-68-5
  • Cinobufotalin, 10 mM in DMSO
  • (1R,2R,2aR,3aS,3bR,5aS,7S,9aR,9bS,11aR)-5a,7-Dihydroxy-9a,11a-dimethyl-1-(2-oxo-2H-pyran-5-yl)hexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-2-yl acetate
  • Chinbufotalin
  • 5beta-Hydroxycinobufagin
  • Cinobufotalin USP/EP/BP
  • Bufa-20,22-dienolide, 16-(acetyloxy)-14,15-epoxy-3,5-dihydroxy-, (3β,5β,15β,16β)-
  • Cinobufotalin Standard
  • 5beta-Hydroxycinobufagin, HPLC≥98%
  • Cinobufotalin, 98%, from animal extracts
  • 14,15BETA-EPOXY-3BETA,5ALPHA,16BETA-TRIHYDROXY-5BETA,20[22]-BUFADIENOLIDE 16-ACETATE
  • 20,22,5BETA-BUFADIENOLID-14BETA,15BETA-EPOXY-3BETA, 5BETA, 6BETA-TRIOL-16-ACETATE
  • CINOBUFOTALIN
  • 5β,20(22)-Bufadienolide-14,15β-epoxy-3β,5α,16β-triol 16-acetate
  • 14,15β-Epoxy-3β,5α,16β-trihydroxy-5β,20(22)-bufadienolide 16-acetate
  • Nsc90326
  • Cinobufotlin
  • 5.beta.-Bufa-20,22-dienolide, 14,15.beta.-epoxy-3.beta.,5,16.beta.-trihydroxy-, 16-acetate
  • 3β,5β-Dihydroxy-16β-acetoxy-14,15β-epoxy-5β-bufa-20,22-dienolide
  • 16β-Acetoxy-14,15β-epoxy-3β,5-dihydroxy-5β-bufa-20,22-dienolide
  • 16β-(Acetyloxy)-14,15β-epoxy-3β,5-dihydroxy-5β,14β-bufa-20,22-dienolide
  • Bufa-20,22-dienolide, 16- (acetyloxy)-14,15-epoxy-3,5-dihydroxy-, (3.beta.,5.beta.,15.beta.,16.beta.)-
  • 5-b-Bufa-20,22-dienolide, 14,15-b-epoxy-3-b,5,16-b-trihydroxy, 16-acetate
  • 14,15-Epoxy-14H-cyclopenta[a]phenanthrene, bufa-20,22-dienolide deriv.
  • 5β,20(22)-Bufadienolide-14,15β-epoxy-3β,5α,16β-triol 16-acetate, 14,15β-Epoxy-3β,5α,16β-trihydroxy-5β,20(22)-bufadienolide 16-acetate
  • 14,15b-Epoxy-3b,5a,16b-trihydroxy-5b,20(22)-bufadienolide 16-acetate
  • CINOBUFOTALIN(RG)
  • 14,15-beta-epoxy-3-beta,5,16-beta-trihydroxy-22-dienolid16-5-beta-bufa-2

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