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Hematoxylin

CAS No.517-28-2
Chemical Name:Hematoxylin
CBNumber:CB1382426
Molecular Formula:C16H14O6
Formula Weight:302.28
MOL File:517-28-2.mol

Hematoxylin Property

Melting point 200 °C (dec.)(lit.)
Boiling point 363.32°C (rough estimate)
Density 1.2514 (rough estimate)
bulk density 500kg/m3
vapor pressure 0-0Pa at 20-25℃
refractive index 1.4600 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Soluble in 95% ethanol(1 mg/mL).
form Powder/Solid
Colour Index 75290
pka 6.7(at 25℃)
color Yellow to Brown
PH Range Red (0.0) to yellow (1.0);Pale yellow (5.0) to violet (6.0)
Water Solubility SOLUBLE IN HOT WATER
Sensitive Light Sensitive
λmax 292nm, 445nm, 560nm
Merck 14,4637
BRN 91399
Stability Stable, but may discolour on exposure to light. Incompatible with strong oxidizing agents.
Major Application Plasma displays, textiles, hair dyes, identifying fresh and stale rice, diag-nosing cancer progression, detecting nosing cancer progression, cervical disease, central nervous system malfunctions, detecting genes, breast cancer, collagen in a tissue sample, apoptosis, demyelinating diseases, antigens, treatment of age-related macular degeneration, burns, prostate cancer, diabetesand obesity, viral diseases, neoplasms, peripheral neural and vascular ailments, skin disorders, biotechnological applications, reference standard materials for cytology, histology andimmunohistochemistry
InChIKey WZUVPPKBWHMQCE-UHFFFAOYSA-N
LogP 0.3 at 30℃ and pH6.9
CAS DataBase Reference 517-28-2
EWG's Food Scores 1
FDA UNII YKM8PY2Z55
EPA Substance Registry System Hematoxylin (517-28-2)
UNSPSC Code 41116130
NACRES NA.47

Safety

Hazard Codes :Xn,Xi
Risk Statements :22-36/37/38
Safety Statements :26-36
WGK Germany :2
RTECS :MH7875000
TSCA :Yes
HS Code :32030019
Hazardous Substances Data :517-28-2(Hazardous Substances Data)

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H319
Precautionary statements P264-P280-P305+P351+P338-P337+P313

Hematoxylin Price More Price(12)

Brand: Sigma-Aldrich(India)
Product number: H9627
Product name : Hematoxylin
Purity:
Packaging: 25G
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Brand: Sigma-Aldrich(India)
Product number: H9627
Product name : Hematoxylin
Purity:
Packaging: 100G
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Brand: Sigma-Aldrich(India)
Product number: H9627
Product name : Hematoxylin
Purity:
Packaging: 5X100G
Price: ₹112332
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Brand: Sigma-Aldrich(India)
Product number: H3136
Product name : Hematoxylin
Purity: certified by the Biological Stain Commission
Packaging: 25G
Price: ₹8269.5
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Brand: Sigma-Aldrich(India)
Product number: 1.04302
Product name : Hematoxylin cryst. (C.I. 75290)
Purity: for microscopy
Packaging: 25G
Price: ₹21320
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Hematoxylin Chemical Properties,Usage,Production

Chemical Properties light brown crystals or powder
Uses Hematoxylin and eosin together make up Hematoxylin and eosin stain, one of the most commonly used stains in histology. Metal-haematein complexes are used to stain cell nuclei prior to examination under a microscope. Structures that stain with iron- or aluminum-haematein are often called basophilic, even though the mechanism of the staining is different from that of staining with basic dyes.
Uses Colorant in inks, biological stains.
Definition ChEBI: (+)-haematoxylin is a haematoxylin. It is an enantiomer of a (-)-haematoxylin.
General Description White to yellowish crystals that redden on exposure to light.
Air & Water Reactions Soluble in hot water, slightly water soluble in cold .
Reactivity Profile Sensitive to light. .
Hazard May be carcinogenic.
Biological Activity Hematoxylin is an organic stain which chelates with metal ions and binds to DNA and RNA. It is used for staining nucleus of the cells. Hematoxylin along with eosin stain is used in the diagnosis of invasion stage in tumors.
storage Store at RT
Purification Methods Hematoxylin recrystallises from H2O (as trihydrate) in white-yellow crystals which become red on exposure to light and then melt at 100-120o. It has been recrystallised from Me2CO/*C6H6. It has been recrystallised as well from dilute aqueous NaHSO3 until colourless and is soluble in alkali, borax and glycerol. Store it in the dark below 0o. [Morsingh & Robinson Tetrahedron 26 182 1970, Dann & Hofmann Chem Ber 98 1498 1955, Beilstein 17/8 V 469.]