OTX 008

Uses

OTX008 is a selective inhibitor of galectin-1.

Biological Activity

OTX008 (Calixarene 0118, PTX008), a calixarene derivative, is a selective inhibitor of galectin-1 (Gal1) with antitumor activity.

in vivo

target

Target	Value
galectin-1 ()

IC 50

Galectin-1

References

[1] Astorgues-Xerri L, et al. OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis. Eur J Cancer. 2014 Sep;50(14):2463-77. DOI:10.1016/j.ejca.2014.06.015
[2] Zucchetti M, et al. Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib. Cancer Chemother Pharmacol. 2013 Oct;72(4):879-87. DOI:10.1007/s00280-013-2270-2