ChemicalBook > CAS DataBase List > 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-

2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-

2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Structure
2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-
  • CAS No.452339-73-0
  • Chemical Name:2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-
  • CBNumber:CB12563399
  • Molecular Formula:C13H15NO4
  • Formula Weight:249.26
  • MOL File:452339-73-0.mol
2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Property
  • Melting point 160 - 163°C
  • Boiling point 489.6±45.0 °C(Predicted)
  • Density 1.223±0.06 g/cm3(Predicted)
  • storage temp. Inert atmosphere,Store in freezer, under -20°C
  • solubility Chloroform (Sparingly), Methanol (Slightly)
  • pka 12.29±0.40(Predicted)
  • form Solid
  • color White to Off-White
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Chemical Properties,Usage,Production

  • Uses (5R)-5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-2-Oxazolidinone (2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-) is a reagent applied in the preparation of alkyl-linked di-phenyl aminoalcohols as long-acting β2 adrenergic receptor agonist. It is used as an antedrug.
  • Synthesis (R)-2-amino-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethan-1-ol (29.8g, 134.0mmol, 1.0eq.) and tetrahydrofuran (300mL) were added to the reaction flask under nitrogen protection, the reaction solution was heated to 40-60°C, and N, N'- Carbonyldiimidazole (22.7 g, 140.0 mmol, 1.05 eq.).After the addition, the reaction solution was kept at a temperature of 40-60° C. and stirred until the raw material reaction was completed. After the reaction, the solution was cooled to 15-30° C., and water (400 mL) was added. Then, the mixture was continuously cooled to 0-10°C and kept stirring. The precipitated solid was filtered, and the filter cake was washed with water. The filter cake was collected and dried under reduced pressure to obtain 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- (30 g, 120.4 mmol, 89.9% yield).
    2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-
2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Preparation Products And Raw materials
Raw materials
Preparation Products
2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Suppliers
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2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Spectrum
452339-73-0, 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-Related Search:
  • 452339-73-0
  • Intermediate
  • 化学试剂
  • 吡啶衍生物
  • 维兰特罗中间体
  • 中间体
  • 5R-(5R)-5-(2,2-二甲基-4H-1,3-苯并二氧杂环己-6-基)-1,3-恶唑烷-2-酮
  • 维兰特罗杂质74
  • (R)-5-(2,2-二甲基-4H-苯并[D][1,3]二噁英-6-基)-2-噁唑烷酮
  • KSM-2异构体
  • (5R)-5-(2,2-二甲基-4H-1,3-苯并二恶英-6-基)-1,3-奥沙唑丁-2-酮
  • 2-恶唑烷酮,5-(-2,2-二甲基-4H-1,3-苯并二氧-6-YL),(5R)-(中7)
  • 维兰特罗杂质29
  • (5R)-5-(2,2-二甲基-4H-1,3-苯并二恶英-6-基)-1,3-恶唑烷-2-酮
  • (5R)-5-(2,2-二甲基-4H-1,3-苯并二氧杂环己-6-基)-1,3-噁唑烷-2-酮
  • 维兰特罗关键中间体
  • (R)-5-(2,2-二甲基-4H-苯并[D][1,3]二氧杂环己烯-6-基)恶唑烷-2-酮
  • (5R)-5-(2,2-二甲基-4H-1,3-苯并二氧杂环己-6-基)-1,3-恶唑烷-2-酮
  • 2-恶唑烷酮, 5-(2,2-二甲基-4H-1,3-苯并二氧-6-YL)
  • 2-恶唑烷酮, 5-(2,2-二甲基-4H-1,3-苯并二氧-6-YL), (5R)-
  • 452339-73-0
  • 5R-(5R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
  • (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxazolidinone
  • (5R) -5- (2,2-dimethyl-4H-1,3-benzodioxane-6-yl) -1,3-oxazolidine-2-one
  • Vilanterol Impurity 74
  • (R)-5-(2,2-demethyl-4H-benzo[d] [1,3] dioxin -6-yl)oxazolidin-2-one
  • (R)-5-(2,2-DIMETHYL-4H-BENZO[D][1,3]DIOXIN-6-YL)OXAZOLIDIN-2-ONE
  • (5R)-5-(2,2-DiMethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
  • TIANFU CHEM 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-
  • (5R)-2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-y...
  • Vilanterol internate 1
  • Vilanterol Impurity 29
  • BNKY020-VT04
  • (R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
  • (5R)-2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)
  • 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-

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