ChemicalBook > CAS DataBase List > Magnesium L-Threonate

Magnesium L-Threonate

Physical Form

CAS No.778571-57-6
Chemical Name:Magnesium L-Threonate
CBNumber:CB12489934
Molecular Formula:C8H14MgO10
Formula Weight:294.5
MOL File:778571-57-6.mol

Magnesium L-Threonate Property

storage temp. Inert atmosphere,Room Temperature
form Solid
color White to off-white
InChI InChI=1S/2C4H8O5.Mg/c2*5-1-2(6)3(7)4(8)9;/h2*2-3,5-7H,1H2,(H,8,9);/q;;+2/p-2
InChIKey YVJOHOWNFPQSPP-UHFFFAOYSA-L
SMILES C(C1=O[Mg+2]2(O=C(C(O)C(O)CO)[O-]2)[O-]1)(O)C(O)CO
FDA UNII 1Y26ZZ0OTM
NCI Drug Dictionary magnesium L-threonate

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H319-H317
Precautionary statements P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P280-P305+P351+P338-P337+P313P

Magnesium L-Threonate Chemical Properties,Usage,Production

Physical Form Solid
Description L-Threonic acid magnesium salt (Magnesium L-Threonate) is the enantiomer of Threonic acid and a metabolite of vitamin C. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent.
Physical properties Appearance:White or almost white powder.
Uses Magnesium(2+) Ion Bis((2r,3s)-2,3,4-Trihydroxybutanoate) is a useful research chemical.
Uses Preclinical work demonstrates that L-Threonic Acid Magnesium Salt (LTAMS) administration is associated with neurobiological and neurofunctional effects that could offer clinical benefits in ADHD treatment.
Application Raw material of healthcare products.A Dietary Supplement.Laboratory research
benefits Magnesium L-Threonate could enhance cognition, improve body magnesium status, and reduce fluctuation in cognitive ability, brain anti-ageing, and memory improvement.
Biological Functions Magnesium L-Threonate (MgT) is a compound composed of magnesium ions and threonate, which is physiologically present in the brain and is used as a magnesium supplement. Unlike other magnesium compounds, MgT significantly increases magnesium ion levels in cerebrospinal fluid, has neuroprotective effects, and has effects on cognition, memory, and mood. MgT can prevent the reduction of glutamatergic synaptic transmission under Alzheimer's disease-like pathological conditions; it can also improve sleep quality, especially deep/REM sleep stages, improve mood, energy, alertness, and daily activities and productivity.^[1-2]
Side effects Magnesium L-Threonate may cause side effects such as headache, diarrhea, nausea, cramping, or stomach irritation when used as a supplement. Taking it with food can help reduce these side effects. Excessive use can also lead to magnesium toxicity, which can cause symptoms such as numbness or tingling in the face, nausea, vomiting, muscle weakness, low blood pressure, and irregular heartbeats.
References [1] CONGCONG FU . Effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination and blood–brain barrier integrity in mice with neuromyelitis optica spectrum disorder[J]. Brain Research, 2024, 1846: Article 149234. DOI:10.1016/j.brainres.2024.149234.
[2] HEATHER A. HAUSENBLAS . Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial[J]. Sleep Medicine: X, 2024, 8: Article 100121. DOI:10.1016/j.sleepx.2024.100121.