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2-Deoxy-D-ribose

CAS No.533-67-5
Chemical Name:2-Deoxy-D-ribose
CBNumber:CB5315585
Molecular Formula:C5H10O4
Formula Weight:134.13
MOL File:533-67-5.mol

2-Deoxy-D-ribose Property

Melting point 89-90 °C(lit.)
Boiling point 167.23°C (rough estimate)
alpha -57 º (c=1, H2O, 24hr)
Density 1.0590 (rough estimate)
refractive index -56 ° (C=1, H2O)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form Crystalline Powder
pka 12.61(at 25℃)
color White to slightly yellow
optical activity [α]22/D 59°, c = 1 in H2O
Water Solubility soluble
Sensitive Hygroscopic
Merck 14,2908
BRN 1721978
Stability Hygroscopic
InChIKey ASJSAQIRZKANQN-CRCLSJGQSA-N
CAS DataBase Reference 533-67-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII LSW4H01241
NIST Chemistry Reference D-Erythro-pentose, 2-deoxy-(533-67-5)
EPA Substance Registry System D-erythro-Pentose, 2-deoxy- (533-67-5)
UNSPSC Code 12352201
NACRES NA.25

Safety

Hazard Codes :Xn,Xi
Risk Statements :20/21/22-36/37/38
Safety Statements :24/25-37/39-36-26
WGK Germany :3
RTECS :SB7230000
F :3-10
TSCA :Yes
HS Code :29400000

NFPA 704:

	1
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319-H332-H335
Precautionary statements P261-P280-P305+P351+P338

2-Deoxy-D-ribose Price More Price(20)

Brand: Sigma-Aldrich(India)
Product number: D5899
Product name : 2-Deoxy-D-ribose
Purity: suitable for cell culture, BioReagent
Packaging: 10MG
Price: ₹2165
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 31170
Product name : 2-Deoxy-D-ribose
Purity: ≥99.0% (TLC)
Packaging: 1G
Price: ₹1818.6
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: D5899
Product name : 2-Deoxy-D-ribose
Purity: suitable for cell culture, BioReagent
Packaging: 1G
Price: ₹4438.25
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 31170
Product name : 2-Deoxy-D-ribose
Purity: ≥99.0% (TLC)
Packaging: 5G
Price: ₹7534.2
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 31170
Product name : 2-Deoxy-D-ribose
Purity: ≥99.0% (TLC)
Packaging: 25G
Price: ₹17655.58
Updated: 2022/06/14
Buy: Buy

2-Deoxy-D-ribose Chemical Properties,Usage,Production

Description 2-deoxy-D-Ribose is a reducing sugar formed as a degradation product during metabolism of thymidine by thymidine phosphorylase. It increases levels of reactive oxygen species (ROS) in HL-60 human leukemia cells when used at a concentration of 15 mM. 2-deoxy-D-Ribose (10 μM) induces tubulogenesis and migration of bovine aortic endothelial (BAE) cells. Topical administration of 2-deoxy-D-ribose increases blood vessel formation and accelerates wound healing in a rat full-thickness cutaneous wound model.
Uses 2-Deoxy-D-ribose (2dDR) can be used to prepare multifunctional wound dressings capable of inducing rapid angiogenesis with antimicrobial activity, such as 2dDR-SA hydrogel. The gel can be used to stimulate wound healing and treat superficial skin wounds, including chronic wound care. In addition, 2dDR gel has the potential to treat androgenetic alopecia and other causes of alopecia areata.
Uses 2-Deoxy-D-ribose is used as a precursor to deoxyribonucleic acid. It induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione. Further, it is used in the synthesis of optically active dipyrrolyl alkanols from pyrroles on the surface of montmorillonite KSF clay.
Definition ChEBI: 2-deoxy-D-ribose is a deoxypentose that is D-ribose in which the hydroxy group at position C-2 is replaced by hydrogen. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is functionally related to a D-ribose.
benefits Hair Regrowth in Mice: Applying a small dose of 2-deoxy-D-ribose to mice models led to significant hair regrowth.
Blood Vessel Formation: The hair regrowth was linked to forming new blood vessels, enhancing blood supply to hair follicles.
Comparable to Minoxidil: The effectiveness of 2-deoxy-D-ribose in regrowing hair was similar to that of Minoxidil, a widely used hair loss treatment.
Biological Activity 2-Deoxy-D-ribose (2dDR) is a D-isomer of a deoxypentose monosaccharide in which a hydrogen atom is present with a hydroxyl group at the C-2 position in place of the hydroxyl group. 2dDR is known to enhance tubulogenesis, prevent hypoxia-induced apoptosis, and boost VEGF and IL-8 production of ECs in vitro, consistent with the stimulatory effects of 2dDR on cell proliferation and migration. 2dDR also stimulated angiogenesis, proliferation of endothelial cells, and accelerated wound healing in rat models. Additionally, 2dDR can be loaded into several biomaterials for prolonged release over several days to promote the growth of neonatal blood vessels[1].
References [1] Anjum, Muhammad Awais et al. “Stimulation of hair regrowth in an animal model of androgenic alopecia using 2-deoxy-D-ribose.” Frontiers in Pharmacology 44 16 (2024).