ChemicalBook > CAS DataBase List > 1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE

1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE

1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE Structure
1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE
  • CAS No.184845-43-0
  • Chemical Name:1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE
  • CBNumber:CB12446542
  • Molecular Formula:C27H30N2O2
  • Formula Weight:414.54
  • MOL File:184845-43-0.mol
1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE Property
  • Boiling point 623.5±55.0 °C(Predicted)
  • Density 1.17±0.1 g/cm3(Predicted)
  • storage temp. Desiccate at RT
  • pka 14.13±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE Chemical Properties,Usage,Production

  • Uses NNC 05-2090 Hydrochloride is a GABA uptake inhibitor displaying selectivity for BGT-1 (mGAT-2) transporters.
  • Biological Activity GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (K i values are 1.4, 15, 19 and 41 μ M for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α 1 - and D 2 -receptors (IC 50 values are 266 and 1632 nM respectively).
  • in vivo

    NNC 05-2090 (intraperitoneal injection) dose-dependently protects against maximal electroshock (MES) in mice with an ED50 values of 73 μmol/kg, and shows ED50 values against tonic and clonic convulsions in DBA/2 mice of 19 and 26 μmol /kg, respectively[1]. NNC 05-2090 (0.01, 0.1 and 0.3 mg/kg; i.p. or i.,t., once) reverses mechanical allodynia in (partial sciatic nerve ligation) PSL model mice[3].

1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
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1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE Suppliers
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1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE Spectrum
184845-43-0, 1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDERelated Search:
  • 抑制剂
  • C27H30N2O2HCl
  • 1-(3-(9H-咔唑-9-基)丙基)-4-(2-甲氧基苯基)哌啶-4-醇
  • NNC 05-2090,GABA UPTAKE抑制剂
  • 化合物 NNC052090
  • 化合物 T28183
  • 184845-43-0
  • NNC 05-2090, GABA uptake inhibitor
  • 4-Piperidinol, 1-[3-(9H-carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-
  • NNC 05-2090HCl
  • NNC 05-2090 HYDROCHLORIDE
  • 1-[3-(9H-CARBAZOL-9-YL)PROPYL]-4-(2-METHOXYPHENYL)-4-PIPERIDINOL HYDROCHLORIDE

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