ChemicalBook > CAS DataBase List > 1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE

1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE

1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE Structure
1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE
  • CAS No.57756-45-3
  • Chemical Name:1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE
  • CBNumber:CB1212002
  • Molecular Formula:C15H18N2
  • Formula Weight:226.32
  • MOL File:57756-45-3.mol
1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE Property
  • Melting point 114-115℃
  • storage temp. Desiccate at +4°C
  • FDA UNII V59TZ3ACG6
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE Chemical Properties,Usage,Production

  • Uses WAY 629 is a selective SR-2C agonist. Potent and efficacious 5-HT2C receptor agonists.
  • Definition ChEBI: LSM-3233 is a member of carbazoles.
  • Biological Activity Selective 5-HT 2C agonist. K i values are 56, 2350, 1575 and 815 nM for human recombinant 5-HT 2C , 5-HT 2A , 5-HT 6 and 5-HT 7 receptors respectively. Stimulates intracellular Ca 2+ mobilization in CHO cells expressing human 5-HT 2C receptors (EC 50 = 72 nM). Reduces food intake in rats.
  • in vivo

    WAY 629 (30 mg/kg; i.p.) decreases feeding behavior in rats[1].
    WAY 629 (21 mg/kg; i.p.) decreases the expression of NPY mRNA in mice brains[2].

    Animal Model:WT mice[2]
    Dosage:21 mg/kg
    Administration:I.p.
    Result:Decreased the expression of NPY mRNA.
  • IC 50 5-HT2C Receptor: 426 nM (EC50); 5-HT2A Receptor: 260000 nM (EC50)
1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE Suppliers
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1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE Spectrum
57756-45-3, 1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDERelated Search:
  • Serotonin receptor
  • 抑制剂
  • C15H18N2HCl
  • 化合物 WAY 629
  • WAY 629盐酸盐
  • 4,5,6,7,9,10,11,12-八氢[1,4]二氮杂卓并[6,7,1-JK]咔唑
  • 57756-45-3
  • WAY 629 hydrochlorid
  • [1,4]Diazepino[6,7,1-jk]carbazole, 4,5,6,7,9,10,11,12-octahydro-
  • 4,5,6,7,9,10,11,12-Octahydro[1,4]diazepino[6,7,1-jk]carbazole
  • 1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE
  • WAY 629 HYDROCHLORIDE

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