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Bupivacaine-d9

Bupivacaine-d9 Structure
Bupivacaine-d9
  • CAS No.474668-57-0
  • Chemical Name:Bupivacaine-d9
  • CBNumber:CB12104039
  • Molecular Formula:C18H28N2O
  • Formula Weight:288.44
  • MOL File:474668-57-0.mol
Bupivacaine-d9 Property
  • storage temp. Store at -20°C
  • solubility DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml
  • form A solid
  • color White to off-white
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302+H312+H332-H315-H319
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501

Bupivacaine-d9 Chemical Properties,Usage,Production

  • Uses (±)-Bupivacaine-d9 (butyl-d9) is an internal standard, useful for the detection of corticosteroids in human plasma.
  • Biological Activity Bupivacaine-d9 is intended for use as an internal standard for the quantification of bupivacaine by GC- or LC-MS. Bupivacaine is a sodium channel blocker and local anesthetic.1,2 It inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner and inhibits synaptic transmission in rat sympathetic ganglia, increasing the firing threshold when used at a concentration of 200 nM.3,4 Bupivacaine (10 μM) blocks cardiac sodium channels in a use-dependent manner and inhibits respiration in cardiac cell mitochondria when palmitoyl-carnitine or acetyl-carnitine are used as substrates (IC50s = 0.78 and 0.37 mM, respectively).1,5 It also reduces thermal hyperplasia in a rat model of sciatic ligation injury when 0.6 ml of a 0.5% solution is administered into the perinerve space, and the duration of this effect is extended by co-administration of the NMDA receptor antagonist MK-801 .2 Formulations containing bupivacaine have been used as local anesthetics for surgery, oral surgery, and dental procedures and for anesthetic purposes in research studies using animals.
  • IC 50 NMDA Receptor
  • References 1.Arlock, P.Actions of three local anaesthetics: lidocaine, bupivacaine and ropivacaine on guinea pig papillary muscle sodium channels (Vmax)Pharmacol. Toxicol.63(2)96-104(1988) 2.Mao, J., Price, D.D., Mayer, D.J., et al.Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathyBrain Res.576(2)254-262(1992) 3.Olschewski, A., Hempelmann, G., Vogel, W., et al.Blockade of Na+ and K+ currents by local anesthetics in the dorsal horn neurons of the spinal cordAnesthesiology88(1)172-179(1998) 4.Tabatabai, M., and Booth, A.M.Mechanism of action of local anesthetics on synaptic transmission in the ratAnesth. Analg.71(2)149-157(1990) 5.Weinberg, G.L., Palmer, J.W., VadeBoncouer, T.R., et al.Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondriaAnesthesiology92(2)523-528(2000)
Bupivacaine-d9 Preparation Products And Raw materials
Raw materials
Preparation Products
Bupivacaine-d9 Suppliers
Global(40)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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  • Supplier： Clearsynth Labs Limited
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  • Email：info@clearsynth.com
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  • Supplier： TOSUN PHARM
  • Tel：020-61855200<br/>13326451905
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Bupivacaine-d9 Spectrum
474668-57-0, Bupivacaine-d9Related Search:
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  • 抑制剂
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  • 47668-57-0
  • 丁基-2H9]-(±)-布比卡因
  • 布比卡因-D9(布比卡因杂质10)
  • 2H9]-布比卡因
  • 布比卡因-D9
  • 布比卡因-D9氘代
  • RAC-布比卡因-D9
  • 474668-57-0
  • butyl-2H9]-(±)-Bupivacaine
  • 2H9]-Bupivacaine
  • Bupivacaine D9Q: What is Bupivacaine D9 Q: What is the CAS Number of Bupivacaine D9 Q: What is the storage condition of Bupivacaine D9 Q: What are the applications of Bupivacaine D9
  • rac-Bupivacaine-d9
  • Bupivacaine-d9

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