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H-LYS-D-PRO-THR-OH

H-LYS-D-PRO-THR-OH Structure
H-LYS-D-PRO-THR-OH
  • CAS No.117027-34-6
  • Chemical Name:H-LYS-D-PRO-THR-OH
  • CBNumber:CB1159125
  • Molecular Formula:C15H28N4O5
  • Formula Weight:344.41
  • MOL File:117027-34-6.mol
H-LYS-D-PRO-THR-OH Property
  • storage temp. −20°C
  • solubility H2O: 10 mg/mL, clear, colorless
  • form Solid
  • color White to off-white
  • FDA UNII 9VU41E2PRZ
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
  • F  :10
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

H-LYS-D-PRO-THR-OH Chemical Properties,Usage,Production

  • Uses Lys-D-Pro-Thr, an IL-1beta analogue, is a potent IL-1 inhibitor. Lys-D-Pro-Thr inhibits the protective effects of IL-1 beta[1][2].
  • in vivo

    Lys-D-Pro-Thr (10 mg/kg; IP; for 4 days) inhibits the protective effect of fMLP (HY-P0224) and that of MMK-1 (HY-P1117) against Etoposide (HY-13629)-induced alopecia[1].

    Animal Model:11-d-old rats[1]
    Dosage:10 mg/kg
    Administration:IP; for 4 days
    Result:Inhibited the protective effect of fMLP and that of MMK-1 against Etoposide-induced alopecia. It alone did not induce alopecia.
  • IC 50 IL-1
  • References [1] Takahiro Tsuruki, et al. Mechanism of the protective effect of intraperitoneally administered agonists for formyl peptide receptors against chemotherapy-induced alopecia. Biosci Biotechnol Biochem. 2007 May;71(5):1198-202. DOI:10.1271/bbb.60656
    [2] Y Uehara, et al. Central administration of Lys-D-Pro-Thr, an interleukin-1 beta 193-195 analogue, stimulates feeding in rats. Neuropeptides. 1991 May;19(1):9-11. DOI:10.1016/0143-4179(91)90067-s
H-LYS-D-PRO-THR-OH Preparation Products And Raw materials
Raw materials
Preparation Products
H-LYS-D-PRO-THR-OH Suppliers
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H-LYS-D-PRO-THR-OH Spectrum
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