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N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid

N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid Structure
N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid
  • CAS No.103878-83-7
  • Chemical Name:N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid
  • CBNumber:CB11448718
  • Molecular Formula:C8H10ClN3O.HCl
  • Formula Weight:0
  • MOL File:103878-83-7.mol
N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid Property
  • Melting point 193-195°
  • storage temp. Desiccate at RT
  • solubility Soluble to 100 mM in water and to 100 mM in DMSO
  • form Powder
  • pka 8.9(at 25℃)
  • FDA UNII PI150J9ZX1
Safety
  • Toxicity :LD50 orally in mice: 1000-2000 mg/kg (Imhof, Kyburz, 1986)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid Chemical Properties,Usage,Production

  • Uses Lazabemide Hydrochloride is a reversible and selective inhibitor of MAO-A and MAO-B, both of which oxidatively deaminate neurotransmitter and xenobiotic amines.
  • Uses Treatment of Alzheimer’s disease.
  • Definition ChEBI: Lazabemide hydrochloride is a pyridinecarboxamide.
  • brand name Tempium (Hoffmann-LaRoche).
  • Biological Activity Selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC 50 values are 0.03 and > 100 μ M for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC 50 values are 86, 123 and > 500 μ M for noradrenalin, serotonin and dopamine uptake respectively).
  • storage Desiccate at RT
N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid Preparation Products And Raw materials
Raw materials
Preparation Products
N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid Suppliers
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N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid Spectrum
103878-83-7, N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochloridRelated Search:
  • Monoamine Oxidase
  • 抑制剂
  • 药靶配体
  • C8H10ClN3OHCl
  • LAZABEMIDE盐酸盐
  • 拉扎贝胺盐酸盐
  • 103878-83-7
  • N-(2-aminoethyl)-5-chloropicolinamide hydrochloride
  • Lazabemide hydrochloride , Lazabemide HCl
  • ichemia,Lazabemide,DOPAC,MAO,radical generation,Ro 19-6327,disease,alzheimer′s,Inhibitor,inhibit,Lazabemide hydrochloride,Monoamine Oxidase,smoking cessation,parkinson
  • N-(2-Aminoethyl)-5-chlor-2-pyridincarbox
  • JMFKTFLARGGXCC-UHFFFAOYSA-N
  • N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride
  • TeMpiuM
  • Ro 19-6327/001
  • 2-PyridinecarboxaMide, N-(2-aMinoethyl)-5-chloro-, Monohydrochloride
  • N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid

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