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perlapine

perlapine Structure
perlapine
  • CAS No.1977-11-3
  • Chemical Name:perlapine
  • CBNumber:CB11388928
  • Molecular Formula:C19H21N3
  • Formula Weight:291.39
  • MOL File:1977-11-3.mol
perlapine Property
  • Melting point 136-138°
  • Boiling point 423.4°C (rough estimate)
  • Density 1.0521 (rough estimate)
  • refractive index 1.6080 (estimate)
  • storage temp. Store at -20°C
  • solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 5 mg/ml
  • form A crystalline solid
  • pka 8.00±0.20(Predicted)
  • color White
  • FDA UNII 4N8UJJ27IM
Safety
  • Toxicity :LD50 in male, female mice, rats (mg/kg): 61, 61, 60, 66 i.v.; 250, 300, 480, 420 s.c., 270, 280, 660, 720 orally (Yokotani)
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312-P330-P501

perlapine Chemical Properties,Usage,Production

  • Uses Perlapine exhibits antipsychotic activity and blocks dopamine and serotonin receptors. Perlapine is also a novel agonist of hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD).
  • Uses Perlapine is an atypical neuroleptic that blocks dopamine and serotonin (5-HT) receptors (Kis = 60, 30, and 30 nM for D2, D4, and 5-HT2A, respectively). Perlapine is also an agonist for hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD) derived from the human muscarinic acetylcholine M3 receptor that activates neuronal firing. Perlapine displays >10,000-fold selectivity for hM3Dq over hM3.
  • Definition ChEBI: Perlapine is an organic molecular entity.
  • storage Room temperature
perlapine Preparation Products And Raw materials
Raw materials
Preparation Products
perlapine Suppliers
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  • Supplier： TargetMol Chemicals Inc.
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perlapine Spectrum
1977-11-3, perlapineRelated Search:
  • 抑制剂
  • 化合物 PERLAPINE
  • 1977-11-3
  • 11H-Dibenz[b,e]azepine, 6-(4-methyl-1-piperazinyl)-
  • 6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine
  • 6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine
  • Hypnodin
  • HF 2333
  • AW 14-2333
  • 6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepin

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