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3-HYDRAZINO-QUINOXALINE-2-THIOL

3-HYDRAZINO-QUINOXALINE-2-THIOL Structure
3-HYDRAZINO-QUINOXALINE-2-THIOL
  • CAS No.13080-21-2
  • Chemical Name:3-HYDRAZINO-QUINOXALINE-2-THIOL
  • CBNumber:CB1135666
  • Molecular Formula:C8H8N4S
  • Formula Weight:192.24
  • MOL File:13080-21-2.mol
3-HYDRAZINO-QUINOXALINE-2-THIOL Property
  • Melting point 254 °C (decomp)(Solv: ethanol (64-17-5))
  • Boiling point 376.1±25.0 °C(Predicted)
  • Density 1.55±0.1 g/cm3(Predicted)
  • pka 7.91±0.20(Predicted)
  • form Solid
  • color Light yellow to yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H370
  • Precautionary statements P501-P260-P270-P264-P308+P311-P405

3-HYDRAZINO-QUINOXALINE-2-THIOL Chemical Properties,Usage,Production

  • Uses HPi1 is a potent, selective and orally active antimicrobial against Helicobacter pylori with an IC50 of 0.24 μM and an MIC of 0.08-0.16 μg/mL. HPi1 is inactive against other bacteria, including the gut commensals Lactobacillus casei, Lactobacillus reuteri, and Bifidobacterium longum[1].
  • Biological Activity HPi1 is a potent, selective and orally active antibacterial agent against Helicobacter pylori with IC50 of 0.24 μM and MIC of 0.08-0.16 μg/mL. It is inactive against other bacteria, including the enteric bacteria Lactobacillus casei, Lactobacillus reuteri and Bifidobacterium longum.
  • in vitro

    The MIC against H. pylori isolates ranged from 0.002-0.032 μg/mL (0.01-0.17 μM) in the agar dilution assay. HPi1 is effective against the clarithromycin-resistant strains ARHp172 (MIC of 0.004–0.016 μg/mL) and ARHp246 (MIC of 0.008–0.032 μg/mL).
    HPi1 has some activity against the Bacteroides species , but at concentrations at least 18- fold higher than the H. pylori MIC. More potent activity is detected for Campylobacter jejuni with an MIC of 0.3 μg/mL.
    HPi1 has good physicochemical and pharmacological properties, including determining the aqueous solubility (19 μg/mL), human plasma protein binding (93% bound), stability with human liver microsomes (T 1/2 of 1.3 hours) and the ability to passively permeate membranes.

  • in vivo

    HPi1 (6.25-50 mg/kg; Oral gavage; once a day; for 3 days; female C57BL/6 mice) treatment decreases colony counts below the limit of detection at doses of 25 or 50 mg/kg/day[1].

    Animal Model:Adult specific-pathogen-free female C57BL/6 mice (6-8-week-old) fed with H. pylori SS1 suspension[1]
    Dosage:6.25 mg/kg, 12.5 mg/kg, 25 mg/kg, 50 mg/kg
    Administration:Oral gavage; once a day; for 3 days
    Result:Reduced colony counts to below the limit of detection.
  • target

    IC50: 0.24 μM ( Helicobacter pylori )
    MIC: 0.08-0.16 μg/mL ( Helicobacter pylori )

  • References [1] Gavrish E, et al. In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori. Antimicrob Agents Chemother. 2014 Jun;58(6):3255-60. DOI:10.1128/AAC.02573-13
3-HYDRAZINO-QUINOXALINE-2-THIOL Preparation Products And Raw materials
Raw materials
Preparation Products
3-HYDRAZINO-QUINOXALINE-2-THIOL Suppliers
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3-HYDRAZINO-QUINOXALINE-2-THIOL Spectrum
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