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macbecin I

macbecin I Structure
macbecin I
  • CAS No.73341-72-7
  • Chemical Name:macbecin I
  • CBNumber:CB11346962
  • Molecular Formula:C30H42N2O8
  • Formula Weight:558.67
  • MOL File:73341-72-7.mol
macbecin I Property
  • Melting point 205-206 °C(Solv: ethanol (64-17-5); water (7732-18-5))
  • Boiling point 736.2±60.0 °C(Predicted)
  • Density 1.17±0.1 g/cm3(Predicted)
  • storage temp. Desiccate at -20°C
  • solubility Soluble in DMSO > 10 mM
  • form Powder
  • pka 8.62±0.70(Predicted)
  • EWG's Food Scores 1
  • FDA UNII GB3Z258LF8
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

macbecin I Chemical Properties,Usage,Production

  • Uses Macbecin I is an ansamycin antibiotic inhibitor of Hsp90 activity.
  • Biological Activity Ansamycin antibiotic compound that inhibits Hsp90 activity (IC 50 = 2 μ M) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC 50 ~ 0.4 μ M) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ).
  • IC 50 HSP90: 2 μM (IC50); HSP90: 0.24 μM (Kd)
macbecin I Preparation Products And Raw materials
Raw materials
Preparation Products
macbecin I Suppliers
Global(26)Suppliers
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macbecin I Spectrum
73341-72-7, macbecin IRelated Search:
  • 抑制剂
  • 化合物 MACBECIN I
  • 化合物 T22960
  • 73341-72-7
  • Macbecin
  • Geldanamycin, 6,17-didemethoxy-15-methoxy-6-methyl-11-O-methyl-, (15R)-
  • (15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin
  • (6S,15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methylgeldanamycin
  • macbecin I

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