ChemicalBook > CAS DataBase List > columbamine

columbamine

columbamine Structure
columbamine
  • CAS No.3621-36-1
  • Chemical Name:columbamine
  • CBNumber:CB11321390
  • Molecular Formula:[C20H20NO4]+.
  • Formula Weight:0
  • MOL File:3621-36-1.mol
columbamine Property
  • Melting point 280-282℃ (methanol )
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • solubility DMSO: soluble
  • form Powder
  • color Light yellow to orange
  • FDA UNII 7T4808FEJW
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H402
  • Precautionary statements P264-P270-P273-P301+P312-P330-P501

columbamine Chemical Properties,Usage,Production

  • Chemical Properties Orange-yellow crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from tomato rhizomes, leaves, green fruits, high in content, and low in mature fruits.
  • Uses Columbamine has antibacterial, anti-inflammatory, antihistamine, cardiotonic, anticancer effects.
  • Definition ChEBI: Columbamine is a berberine alkaloid and an organic heterotetracyclic compound.
  • Biological Activity Columbamine is a quaternary isoquinoline alkaloid extracted from plants.
  • in vivo

    Columbamine (5-20 mg/kg; 23 days) significantly decreases the tumor volumes in a dose-dependent manner in HCT116 xenograft mice model[4].

    Animal Model:Six-weeks-old male BALB/c nude mice (subcutaneously injected with HCT116 and control cells on the opposite flanks of the same mouse)[4]
    Dosage:5, 10, 20 mg/kg
    Administration:Administered to experimental mice for 23 days
    Result:Decreased the tumor volumes in a dose-dependent manner.
  • IC 50 CYP3A4: 30.6 μM (IC50)
columbamine Preparation Products And Raw materials
Raw materials
Preparation Products
columbamine Suppliers
Global(124)Suppliers
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32197
  • Advantage：58
columbamine Spectrum
3621-36-1, columbamineRelated Search:
  • 中药标准品，对照品
  • 抑制剂
  • 药靶配体
  • 试剂
  • 标准品，对照品
  • 标准品 -中药标准品
  • 对照品-中药对照品
  • 标准品-对照品
  • 标准品
  • 中药对照品
  • 对照品，标准品
  • 对照品
  • 植物提取物
  • 非洲防己碱,10 MM DMSO 溶液
  • 2-羟基-3,9,10-三甲氧基-5,6-二氢异喹啉并[3,2-A]异喹啉-7-鎓
  • 洲防已碱
  • 非洲防己碱对照品
  • 非洲防己胺、咖伦明
  • COLUMBAMINE 非洲防己碱
  • 非洲防己碱(标准品)
  • 非洲防已碱
  • 咖伦明
  • 非洲防己胺
  • 3621-36-1
  • Columbamine, 10 mM in DMSO
  • 2-Hydroxy-3,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium
  • Inhibitor,Columbamine,inhibit
  • 3,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2-ol
  • Dibenzo[a,g]quinolizinium,5,6-dihydro-2-hydroxy-3,9,10-trimethoxy-
  • Columbamin
  • Columbamine (Columbamin
  • 5,6-Dihydro-3,9,10-trimethoxydibenzo[a,g]quinolizinium-2-ol
  • 5,6-Dihydro-2-hydroxy-3,9,10-trimethoxydibenzo[a,g]quinolizinium
  • Dehydroisocorypalmine

Home

My