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Glaziovine

Glaziovine Structure
Glaziovine
  • CAS No.17127-48-9
  • Chemical Name:Glaziovine
  • CBNumber:CB11178851
  • Molecular Formula:C18H19NO3
  • Formula Weight:297.35
  • MOL File:17127-48-9.mol
Glaziovine Property
  • Melting point 227-228 °C
  • Boiling point 470.8±45.0 °C(Predicted)
  • Density 1.33±0.1 g/cm3(Predicted)
  • pka 9.76±0.20(Predicted)
  • EWG's Food Scores 1
  • FDA UNII KE7J8A65P6
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Glaziovine Chemical Properties,Usage,Production

  • Originator Suavedol,Simes,Italy,1976
  • Uses (±)-Glaziovine, a proaporphine alkaloid, has anxiolytic activity. (±)-Glaziovine can be used for neuropharmacological research[1].
  • Manufacturing Process The thermal condensation of p-benzyloxyphenylacetic acid and of 3-methoxy- 4-hydroxyphenethylamine occurs and gives, with a yield of 86% to 92%, the N-(3-methoxy-4-hydroxyphenethyl-p-benzyloxyphenyl)acetamide; from this latter, by cyclization according to Bischler-Napieralski with phosphorus oxychloride in acetonitrile, followed by reduction with sodium borohydride, there is obtained with a yield of 75% to 80% the 1-(p-benzyloxybenzyl)-6- methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline, which is methylated with formaldehyde and formic acid giving 1(p-benzyloxybenzyl)-2-methyl-6- methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline with a yield of 90%.
    This intermediate is then nitrated with 65% nitric acid. The nitro compound is then hydrogenated to give a hydroxybenzylamino compound.
    A solution of 94.2 g of 1-(p-hydroxybenzyl)-2-methyl-6-methoxy-7-hydroxy-8- amino-1,2,3,4-tetrahydroisoquinoline in 3 liters of 1N sulfuric acid is supplemented, with stirring, between 0°C and 5°C, with 21 grams of sodium nitrite. The diazonium sulfate solution thus obtained is made alkaline with 2.5 liters of 2N sodium hydroxide: the diazo-oxide which is separated at the outset as a yellow precipitate is redissolved by the excess alkali, the solution is diluted to 10 liters with deaerated water and subjected, in a nitrogen atmosphere at 15°C in a Pyrex glass apparatus, to the radiations of a 2,000 W high-pressure mercury vapor lamp until the yellow hue is discharged (about 30 to 40 minutes). The solution is brought to a pH of 8.6 with hydrochloric acid and is stirred with 1.5 liters of chloroform. The two phases are filtered, the chloroform is separated and the aqueous phase is extracted four times with l .5 liters of chloroform. The extracts are evaporated under reduced pressure to a small volume and percolated through a chromatographic column containing 1.3 kilograms of neutral alumina (activity rating IV of the Brockmann scale). The column is then further eluted with chloroform. The eluates are evaporated under reduced pressure and the residue is recrystallized from ethyl acetate. There are thus obtained 40.2 grams (yield 45% of theory) of pure (+-)-glaziovine, having a melting point of 220°C to 222°C.
  • Therapeutic Function Tranquilizer
  • References [1] F.D. Bellamy, et al. Synthesis of derivatives structurally related to glaziovine. Tetrahedron. Volume 39, Issue 17, 1983, Pages 2803-2806.
Glaziovine Preparation Products And Raw materials
Raw materials
Preparation Products
Glaziovine Suppliers
Global(6)Suppliers
  • Supplier：
    Alchem Pharmtech,Inc.
  • Tel：8485655694
  • Email：sales@alchempharmtech.com
  • Country：United States
  • ProdList：63687
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
Glaziovine Spectrum
17127-48-9, GlaziovineRelated Search:
  • 化合物 T24090
  • 奥可梯木种碱
  • 格拉齐文
  • 17127-48-9
  • Spiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopent[ij]isoquinolin]-4-one, 2',3',8',8'a-tetrahydro-6'-hydroxy-5'-methoxy-1'-methyl-
  • 6'-Hydroxy-5'-methoxy-1'-methyl-2',3',8',8a'-tetrahydro-1'H-spiro[cyclohexa[2,5]diene-1,7'-cyclopenta[ij]isoquinolin]-4-one
  • Glaziovine
  • Unii-ke7J8A65p6
  • Spiro(2,5-cyclohexadiene-1,7'(1'H)-cyclopent(ij)isoquinolin)-4-one, 2',3',8',8'A-tetrahydro-6'-hydroxy-5'-methoxy-1'-methyl-, (+-)- (9ci)
  • Nsc 146052
  • Glaziovinum [inn-latin]
  • Glaziovinum
  • Glaziovina [inn-spanish]
  • Glaziovina
  • Ai3-34588
  • (±)-2',3',8',8'a-Tetrahydro-6'-hydroxy-5'-methoxy-1'-methylspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one
  • (±)-2',3',8',8'a-Tetrahydro-6'-hydroxy-5'-methoxy-1'-methylspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopent[ij]isoquinolin]-4-one

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