Description
Penicillin G-d5 is intended for use as an internal standard for the quantification of penicillin G (Item No. 21615) by GC- or LC-MS. Penicillin G is a β-lactam antibiotic that is effective mainly for Gram-positive bacteria.1 It has MIC90 values of 0.03, 1, and 4 µg/ml for penicillin-susceptible, -intermediate, and -resistant strains of S. pneumoniae, respectively, and 16-128 µg/ml for various Bacteroides isolates in a broth dilution assay.2,3 Formulations containing penicillin G have been used for the treatment of bacterial infections and in livestock production.WARNING This product is not for human or veterinary use.
References
[1] DEMAIN A L. Production of beta-lactam antibiotics and its regulation.[J]. Proceedings of the National Science Council, Republic of China. Part B, Life sciences, 1991, 15 4: 251-265.
[2] G A PANKUCH. Antipneumococcal activities of RP 59500 (quinupristin-dalfopristin), penicillin G, erythromycin, and sparfloxacin determined by MIC and rapid time-kill methodologies.[J]. Antimicrobial Agents and Chemotherapy, 1996, 40 7: 1653-1656. DOI:
10.1128/aac.40.7.1653[3] K E ALDRIDGE. Comparison of the activities of penicillin G and new beta-lactam antibiotics against clinical isolates of Bacteroides species.[J]. Antimicrobial Agents and Chemotherapy, 1984, 26 3: 410-413. DOI:
10.1128/aac.26.3.410
