ChemicalBook > CAS DataBase List > 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one

2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one

2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one Structure
2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one
  • CAS No.17952-82-8
  • Chemical Name:2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one
  • CBNumber:CB0915201
  • Molecular Formula:C11H10N2O
  • Formula Weight:186.21
  • MOL File:17952-82-8.mol
2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one Property
  • Melting point 183-185 °C
  • Boiling point 529.2±39.0 °C(Predicted)
  • Density 1.318±0.06 g/cm3(Predicted)
  • solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
  • form Cryst.
  • pka 15.48±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one Chemical Properties,Usage,Production

  • Uses 1,2,3,4-Tetrahydronorharman-1-one is a manzamine alkaloid with activity against infectious and tropical parasitic diseases from an Indonesian sponge[1].
  • Preparation Tryptamine 380 (9.0 g, 56.2 mmol) and triethylamine (13.8 g, 136.3 mmol) were dissolved in warm toluene (800 mL). Under vigorous stirring, a solution of triphosgene (6.7 g, 22.6 mmol) in toluene (35 mL) was added dropwise and the mixture was stirred for a further 20 min at room temperature. Then, HBr (30% in acetic acid; 13 mL) was added and the mixture was refluxed for 30 min. After cooling to room temperature, water (300 mL) and ethyl acetate (300 mL) were added and, after separation of the layers, the aqueous phase was extracted once more with ethyl acetate (300 mL). The combined organic layers were dried over magnesium sulfate and concentrated in vacuo. The residue was recrystallized from methanol/ethyl acetate (1:1) to afford 7.74 g (74%) of 2,3,4,9-tetrahydro-1H-pyrido[ 3,4-b]indol-1-one 382 as a white solid; mp 184°C.
  • References [1] Karumanchi V Rao, et al. New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge. J Nat Prod. 2003 Jun;66(6):823-8. DOI:10.1021/np020592u
2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one Suppliers
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2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one Spectrum
17952-82-8, 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one Related Search:
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