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(+/-)-BLEBBISTATIN

(+/-)-BLEBBISTATIN Structure
(+/-)-BLEBBISTATIN
  • CAS No.674289-55-5
  • Chemical Name:(+/-)-BLEBBISTATIN
  • CBNumber:CB0787697
  • Molecular Formula:C18H16N2O2
  • Formula Weight:292.33
  • MOL File:674289-55-5.mol
(+/-)-BLEBBISTATIN Property
  • Melting point 210-212°C
  • Boiling point 507.3±60.0 °C(Predicted)
  • Density 1.31±0.1 g/cm3(Predicted)
  • storage temp. −20°C
  • solubility Chloroform (Slightly), Dichloromethane, DMSO, Ethyl Acetate, Methanol
  • pka 11.15±0.20(Predicted)
  • form Bright yellow solid.
  • color Yellow
  • CAS DataBase Reference 674289-55-5
  • FDA UNII 20WC4J7CQ6
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338
(+/-)-BLEBBISTATIN Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: 203390
  • Product name : (±)-Blebbistatin - CAS 674289-55-5 - Calbiochem
  • Purity: (±)-Blebbistatin, CAS 674289-55-5, is a cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts
  • Packaging: 5MG
  • Price: ₹28660
  • Updated: 2022/06/14
  • Buy: Buy

(+/-)-BLEBBISTATIN Chemical Properties,Usage,Production

  • Description (±)-Blebbistatin is a racemic mixture of (–)-blebbistatin and (+)-blebbistatin , the active and inactive forms, respectively. (–)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (–)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 8 μM). Through these effects, (–)-blebbistatin blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. (S)-nitro-Blebbistatin and (R)-nitro-blebbistatin are more stable forms of (–)-blebbistatin and (+)-blebbistatin, respectively. The addition of a nitro group stabilizes the molecules to circumvent their degradation by prolonged blue light exposure. (S)-nitro-Blebbistatin and (R)-nitro-blebbistatin have the same stereochemistry of the active and inactive enantiomers, respectively.
  • Chemical Properties Bright Yellow Solid
  • Uses (±)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50 = 0.5-5.0 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM). Through these effects, blebbistatin blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells. Blebbistatin is inactivated by UV light, which may be particularly important in fluorescent cell imaging applications. Purified enantiomers of Blebbistatin are also available from Cayman ((?)-Blebbistatin - ).
  • Uses Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100μM. (±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one Selective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
  • Definition ChEBI: A pyrroloquinoline that is 1,2,3,3a-tetrahydro-H-pyrrolo[2,3-b]quinolin-4-one substituted by a hydroxy group at position 3a, a methyl group at position 6 and a phenyl group at position 1. It acts as an inhibitor of ATPase ac ivity of non-muscle myosin II.
  • Biological Activity Selective inhibitor of myosin II ATPase activity; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
  • storage Store at +4°C
(+/-)-BLEBBISTATIN Preparation Products And Raw materials
Raw materials
Preparation Products
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(+/-)-BLEBBISTATIN Spectrum
674289-55-5, (+/-)-BLEBBISTATINRelated Search:
  • All Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Inhibitors
  • Chiral Reagents
  • Caspases/Apoptosis
  • 抑制剂
  • 药靶配体
  • 化工
  • (±)-Blebbistatin (DMSO Solution)
  • (±)-BLEBBISTATIN,抑制剂OF MYOSIN II
  • (±)-BLEBBISTATIN (DMSO SOLUTION)
  • (±)-BLEBBISTATIN,抑制剂OF MYOSIN II
  • 3A-羟基-6-甲基-1-苯基-1,2,3,3A-四氢-4H-吡咯并[2,3-B]喹啉-4-酮
  • (±)-BLEBBISTATIN,抑制剂
  • (±)-布莱比他汀
  • 674289-55-5
  • (±)-Blebbistatin, inhibitor of myosin II
  • Blebbistatin, 10 mM in DMSO
  • (±)-Blebbistatin (DMSO Solution)
  • (±)-Blebbistatin, inhibitor of myosin II
  • 3a-Hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
  • E1249 (+/-)-Blebbi- Calbiochem
  • 3a-hydroxy-6-methyl-1-phenyl-3,3a-dihydro-1H-pyrrolo[2,3-b]quinolin-4(2H)-one
  • Blebbistatin,Inhibitor,Myosin,inhibit
  • 3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
  • 4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-Methyl-1-phenyl-
  • (+/-)-BLEBBISTATIN
  • (±)Bebbistatin
  • (3aR)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
  • (3aR)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one
  • (3aS)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one
  • 1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one
  • (+/-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-β]-7-methylquinolin-4-one
  • (+/-)-1,2,3,3A-TETRAHYDRO-3A-HYDROXY-6-METHYL-1-PHENYL-4H-PYRROLO[2,3-B]QUINOLIN-4-ONE
  • (+/-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE
  • (3AS)-(-)-1,2,3,3A-TETRAHYDRO-3A-HYDROXY-6-METHYL-1-PHENYL-4H-PYRROLO[2,3-B]QUINOLIN-4-ONE
  • (R)-(+)-BLEBBISTATIN

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