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NIKKOMYCIN Z

NIKKOMYCIN Z Structure
NIKKOMYCIN Z
  • CAS No.59456-70-1
  • Chemical Name:NIKKOMYCIN Z
  • CBNumber:CB0767000
  • Molecular Formula:C20H25N5O10
  • Formula Weight:495.44
  • MOL File:59456-70-1.mol
NIKKOMYCIN Z Property
  • Density 1.646±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility H2O: soluble5mg/mL
  • form Solid
  • pka 2.70±0.10(Predicted)
  • color White to off-white
  • Water Solubility Water : ≥ 100 mg/mL (201.84 mM)
  • FDA UNII 9Z22C3QQCJ
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26-36
  • WGK Germany  :3
  • RTECS  :BA2928200
  • F  :10
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H335-H315-H319
  • Precautionary statements P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
NIKKOMYCIN Z Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: N8028
  • Product name : Nikkomycin Z from Streptomyces tendae
  • Purity: ≥90% (HPLC)
  • Packaging: 5MG
  • Price: ₹26726.93
  • Updated: 2022/06/14
  • Buy: Buy

NIKKOMYCIN Z Chemical Properties,Usage,Production

  • Description Nucleoside-type antibiotic isolated from culture filtrates of Streptomyces tendae (19). Some analogs were also prepared by mutasynthesis, utilizing a uracil auxotroph of S. tendae.
  • Uses Nikkomycins inhibit the growth of various plant pathogenic fungi but are inactive against bacteria and yeasts. Too susceptible to photodegradation by sunlight to be used in field application, and thus not developed commercially for agricultural use. Among the nikkomycins, nikkomycin Z is an orally active antifungal therapeutic agent for coccidioidomycosis. It is a competitive chitin synthase inhibitor that has been evaluated in mouse models for coccidioidomycosis.
  • Definition ChEBI: A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase.
  • Pharmacology By inhibiting chitin synthetase in fungi, nikkomycins inhibit cell wall synthesis, ultimately causing fungal cells to swell and burst.
  • Metabolism There are no detailed reports on metabolism/transformation of nikkomycins in the environment.
NIKKOMYCIN Z Preparation Products And Raw materials
Raw materials
Preparation Products
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NIKKOMYCIN Z Spectrum
59456-70-1, NIKKOMYCIN ZRelated Search:
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  • β-D-Allofuranuronic acid, 5-[[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-
  • 5-((2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicacid
  • 5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1-(3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid
  • 5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid
  • Nikkomycin Z, Sterptomyces tendae
  • nikkomycin Z from streptomyces tendae
  • neopolyoxinc
  • methyl-1-oxobutyl)amino)-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2h)-pyrimidiny
  • 5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci
  • (2s-(2r*,3r*,4r*))-l)
  • NIKKOMYCIN Z, STREPTOMYCES TENDAE
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