c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS

Uses

ML RR-S2 CDA sodium salt is used as a cyclic dinucleotide used in the treatment of cancer. It activates dendritic cells which induces a specific T-cell mediated immune response against cancer cells.

in vivo

References

[1] LETICIA CORRALES. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.[J]. Cell reports, 2015, 11 7: 1018-1030. DOI: 10.1016/j.celrep.2015.04.031
[2] GILLES BERGER. STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 28: e2111003119. DOI: 10.1073/pnas.2111003119