ChemicalBook > CAS DataBase List > O-Phospho-L-serine

O-Phospho-L-serine

CAS No.407-41-0
Chemical Name:O-Phospho-L-serine
CBNumber:CB0456205
Molecular Formula:C3H8NO6P
Formula Weight:185.07
MOL File:407-41-0.mol

O-Phospho-L-serine Property

Melting point 190 °C(lit.)
alpha [α]D20 +14～+18°(c=5,dil.HCl)
Boiling point 475.4±55.0 °C(Predicted)
Density 1.809±0.06 g/cm3(Predicted)
vapor pressure 0Pa at 20℃
storage temp. under inert gas
solubility H₂O: 50 mg/mL hot, clear, colorless to slightly yellow
form Crystalline Powder
pka pK1:2.08;pK2:5.65;pK3:9.74 (25°C)
color White
optical activity +16.221 (2 mol dm-3 HCl)
biological source mouse
Water Solubility 28.34g/L at 20℃
Merck 14,7363
BRN 1726826
InChIKey BZQFBWGGLXLEPQ-UWTATZPHSA-N
CAS DataBase Reference 407-41-0(CAS DataBase Reference)
FDA UNII VI4F0K069V
UNSPSC Code 12352209
NACRES NA.44

Safety

Hazard Codes :Xn
Risk Statements :21/22
Safety Statements :36/37
RIDADR :UN 3261 8 / PGII
WGK Germany :3
F :10
HS Code :29225090

NFPA 704:

	0
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H314
Precautionary statements P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338

O-Phospho-L-serine Price More Price(11)

Brand: Sigma-Aldrich(India)
Product number: P0878
Product name : O-Phospho-L-serine
Purity:
Packaging: 10MG
Price: ₹2803.68
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: P3430
Product name : Monoclonal Anti-Phosphoserine antibody produced in mouse
Purity: clone PSR-45, ascites fluid
Packaging: 100μL
Price: ₹44055.9
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: P3430
Product name : Monoclonal Anti-Phosphoserine antibody produced in mouse
Purity: clone PSR-45, ascites fluid
Packaging: 0.2ML
Price: ₹64180.2
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: P0878
Product name : O-Phospho-L-serine
Purity:
Packaging: 1G
Price: ₹2890.28
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: P0878
Product name : O-Phospho-L-serine
Purity:
Packaging: 5G
Price: ₹8768.25
Updated: 2022/06/14
Buy: Buy

O-Phospho-L-serine Chemical Properties,Usage,Production

Description O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC₅₀s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.
Chemical Properties White powder
Uses roborant
Uses O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.
Uses L-O-Phosphoserine is the catalytic domain of human protein kinase C β II when complexed with a malemide inhibitor. It is also used in the purification of the Epstein-Barr virus nuclear antigen 2A.
Definition ChEBI: O-phospho-L-serine is the L-enantiomer of O-phosphoserine. It has a role as an EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, an EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor, an EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor and a mouse metabolite. It is a conjugate acid of an O-phosphonato-L-serine(2-). It is an enantiomer of an O-phospho-D-serine.
General Description Monoclonal Anti-Phosphoserine (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.
Flammability and Explosibility Not classified
Biological Activity Group III metabotropic glutamate receptor agonist; analog of L-AP4 (L-(+)-2-Amino-4-phosphonobutyric acid ). Inhibits proliferation and enhances neuronal differentiation in progenitor cells.
Biochem/physiol Actions Protein phosphorylation and dephosphorylation are basic signaling mechanisms that modify protein function in eukaryotic cells. Phosphorylation is a rare posttranslational event in normal tissues, however, the abundance of phosphorylated cellular proteins increases several folds following various activation processes. The main amino acids that are phosphorylated are tyrosine, serine, or threonine (pTyr/pSer/pThr), each having specific kinases that phosphorylate them and specific phosphatases that dephosphorylate them. Mono and polyclonal antibodies directed against phosphorylated residues were generated and found useful as analytical and preparative tools by enabling the identification, quantification, and immunoaffinity isolation of phosphorylated cellular proteins.
storage Room temperature
Purification Methods Recrystallise the phospho-serine by dissolving 10g in H2O (150mL) at 25o, stirring for up to 20minutes. Undissolved material is filtered off (Büchner), and 95% EtOH (85mL) is added dropwise during 4minutes, and set aside at 25o for 3hours, then at 3o overnight. The crystals are washed with 95% EtOH (100mL), then dry Et2O (50mL), and dried in a vacuum (yield 6.5g). A further quantity (1.5g) can be obtained by keeping the mother liquors and washings at -10o for 1 week. The DL-isomer has m 167-170o(dec) after recrystallisation from H2O/EtOH or MeOH. [Neuhaus & Korkes Biochemical Preparations 6 75 1958, Neuhaus & Byrne J Biol Chem 234 113 1959, IR: F.lsch & Mellander Acta Chem Scand 11 1232 1957, Beilstein 4 IV 3120.]