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IBOTENIC ACID

CAS No.2552-55-8
Chemical Name:IBOTENIC ACID
CBNumber:CB0400501
Molecular Formula:C5H6N2O4
Formula Weight:158.11
MOL File:2552-55-8.mol

IBOTENIC ACID Property

Melting point 141-147 °C
Density 1.621±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility H2O: soluble1mg/mL, clear, colorless (with sonication)
form White solid
pka 2.16±0.10(Predicted)
color white
Odor Practically odorless. Faint, meat-like, mild and sweet taste in aqueous dilutions.
Water Solubility Soluble to 10 mM in water and to 100 mM in 1.1eq. NaOH
Stability Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
InChIKey IRJCBFDCFXCWGO-UHFFFAOYSA-N
LogP -1.070 (est)
CAS DataBase Reference 2552-55-8(CAS DataBase Reference)
FDA UNII 44AS82FRSI
UNSPSC Code 12352209
NACRES NA.77

Safety

Hazard Codes :T,Xn
Risk Statements :23/24/25-25-40
Safety Statements :45-38-36/37/39-28A-22-36
RIDADR :1544
WGK Germany :3
RTECS :NY2100000
HazardClass :6.1(b)
PackingGroup :III
Toxicity :LD50 in mice, rats (mg/kg): 15, 42 i.v.; 38, 129 orally (Theobald)

NFPA 704:

	3
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H301
Precautionary statements P264-P270-P301+P310-P405-P501

IBOTENIC ACID Price More Price(5)

Brand: Sigma-Aldrich(India)
Product number: I2765
Product name : Ibotenic acid
Purity: ~95%, solid
Packaging: 1MG
Price: ₹21880
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: I2765
Product name : Ibotenic acid
Purity: ~95%, solid
Packaging: 5MG
Price: ₹65350
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: I2765
Product name : Ibotenic acid
Purity: ~95%, solid
Packaging: 10MG
Price: ₹123750
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: I2765
Product name : Ibotenic acid
Purity: ~95%, solid
Packaging: 25MG
Price: ₹236030
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 5.05024
Product name : Ibotenic Acid - CAS 2552-55-8 - Calbiochem
Purity:
Packaging: 1MG
Price: ₹14100
Updated: 2022/06/14
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IBOTENIC ACID Chemical Properties,Usage,Production

Description Ibotenic acid (60573-88-8) is a conformationally restricted analog of glutamate which occurs naturally in Amanita mascaria and related mushrooms.? It is a non-specific glutamate receptor (both NMDA and mGluR) agonist.1 May be used to induce hippocampal lesioning in rat neurodegeneration models.2,3 Induces lesions in the subiculum in a mouse model of Alzheimer’s disease.4
Chemical Properties Crystalline solid; forms monohydrate; mp151°C (303.8°F) (anhydrous), 145°C (293°F)(monohydrate); soluble in water and alcohol.
Uses Ibotenic acid is a neuroexcitatory amino acid originally isolated from Amanita species that functions as a NMDA and metabotropic glutamate receptor agonist. As a neurotoxin, ibotenic acid is often used to induce brain lesions in animals that model cognitive dysfunctions resulting from neurodegenerative diseases, traumatic brain injury, and stroke.
Uses Ibotenic acid has been used to perform surgery in adult male zebra finches (Taeniopygia guttata) to study reversing reinforcement-induced vocal changes.
Uses Neurobiological tool.
Preparation Isolated from the Japanese fly mushroom. The acid can be produced synthetically.
Definition A isoxazole which, together with muscimol, is largely responsible for the toxicities of a number of mushrooms including those of the genus Amanita. It is a potent excitatory amino acid.
Hazard Neurotoxic; causes motor depression, ataxia, changes in mood, perceptions and feelings.
Health Hazard Ibotenic acid is a potent neurologic aminoacid. It exhibits neuroexcitatory activity andcauses sedative actions on spinal neurons.High doses can cause sleep, hallucinations,distorted perceptions, and nausea. In humansthe symptoms above may be manifested fromingestion of 6–8 mg of ibotenic acid.
LD50 value, oral (mice): 38 mg/kg
LD50 value, intraperitoneal (mice): 15 mg/kg.
Biological Activity NMDA and metabotropic glutamate receptor agonist.
Biochem/physiol Actions Non-selective agonist with preference for NMDA glutamate receptors; neurotoxin; neuroexcitatory amino acid originally isolated from Amanita species.
storage -20°C (desiccate)
Purification Methods It has been converted to the ammonium salt (m 121-123o dec) dissolved in H2O, passed through an Amberlite IR 120 resin (H+ form) and eluted with H2O. The acidic fractions are collected, evaporated to dryness and the residue recrystallises from H2O as the monohydrate (m 144-146o). The anhydrous acid is obtained by making a slurry with MeOH, decanting and evaporating to dryness, and repeating the process twice more to give the anhydrous acid (m 151-152o). Recrystallisation from H2O gives the monohydrate. [Nakamura Chem Pharm Bull Jpn 19 46 1971.] The ethyl ester forms needles when crystallised from a small volume of Et2O and has m 78-79o and IR (CHCl3) with max 35002300 (OH), 1742 (ester C=O), 1628, 1528cm-1, and UV with λmax (EtOH) at 206nm (ε 7,080). The hydrazide has m 174-175o (from MeOH) with IR (KBr) 1656 (C=O)cm-1.
References 1) Nakanishi (1992), Molecular diversity of glutamate receptors and implications for brain function; Science 258 597 2) Jarrard (1989), On the use of ibotenic acid to lesion selectively different components of the hippocampal formation; J. Neurosci. Methods 29 251 3) Isacson and Peschanski (1992), Is there capacity for anatomical and functional repair in the adult somatosensory thalamus?; Exp. Neurol. 115 173 4) George et al. (2014), Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer’s disease; Acta Neuropathol. Commun. 2 17