ChemicalBook > CAS DataBase List > Dothiepin

Dothiepin

Dothiepin Structure
Dothiepin
  • CAS No.113-53-1
  • Chemical Name:Dothiepin
  • CBNumber:CB0378413
  • Molecular Formula:C19H21NS
  • Formula Weight:295.44
  • MOL File:113-53-1.mol
Dothiepin Property
  • Melting point 55-57°
  • Boiling point bp0.05 171-172°
  • Density 1.1022 (rough estimate)
  • refractive index 1.5300 (estimate)
  • storage temp. Refrigerator
  • solubility Chloroform (Slightly), Methanol (Slightly)
  • form Thick Oil to Low-Melting Solid
  • pka 9.35±0.28(Predicted)
  • color Off-White to Light Yellow
  • EWG's Food Scores 1
  • FDA UNII W13O82Z7HL
  • ATC code N06AA16
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H361-H362
  • Precautionary statements P201-P260-P263-P264-P280-P308+P313

Dothiepin Chemical Properties,Usage,Production

  • Chemical Properties Pale Yellow Low Melting Solid
  • History Described in the 1960s by the Czech company Sdruzeni Podniku pro Zdravotnickon Vyrobu; SPOFA (Spofa, 1962)
  • Uses A tricyclic antidepressant.
  • Definition ChEBI: Dothiepin is a dibenzothiepine. It has a role as an antidepressant and an anticoronaviral agent.
  • Synthesis Reference(s) Synthesis (Spofa, 1962): S-Benzylthiosalicylic acid is treated with polyphosphoric acid and the resulting cyclic ketone is reacted with 3-dimethylaminopropyl magnesium chloride to afford an alcohol which is dehydrated with sulfuric acid.
    Synthesis of dosulepin
    Synthesis of dosulepin
  • Clinical Use Dosulepin (also referred to as dothiepin) is a member of the TCA family and has similar clinical uses as amitrip- tyline, thus providing effective treatment of depression (Goldstein and Claghorn, 1980; Lancaster and Gonzales, 1989; Donovan et al., 1991) and also against pain (Feinmann et al., 1984; Caruso et al., 1987) and tinnitus. Like amitriptyline it has sedative properties, however its anti-muscarinic side-effects are less pronounced. Dosulepin is readily absorbed from the GI tract and extensively demethylated while undergoing a first-pass effect. Metabolic pathways include next to hydroxylation and N-oxidation steps, S-oxidation. Elimination half-lifes vary from 14 to 24 hours interindividually (Maguire et al., 1982; Yu et al., 1986; Ilett et al., 1993).
Dothiepin Preparation Products And Raw materials
Raw materials
Preparation Products
Dothiepin Suppliers
Global(48)Suppliers
  • Supplier：
    Xi'an MC Biotech, Co., Ltd.
  • Tel：029-89275612<br/>+8618991951683
  • Email：mcbio_sales@163.com
  • Country：China
  • ProdList：2251
  • Advantage：58
  • Supplier：
    AFINE CHEMICALS LIMITED
  • Tel：+86-0571-85134551
  • Email：sales@afinechem.com
  • Country：China
  • ProdList：15393
  • Advantage：58
  • Supplier：
    GIHI CHEMICALS CO.,LIMITED
  • Tel： +8618058761490
  • Email：info@gihichemicals.com
  • Country：China
  • ProdList：49984
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel： +8613564774135
  • Email：zijue.cai@tsbiochem.com
  • Country：United States
  • ProdList：19888
  • Advantage：58
  • Supplier： J & K SCIENTIFIC LTD.
  • Tel： 18210857532
  • Email：jkinfo@jkchemical.com
  • Country：China
  • ProdList：94657
  • Advantage：76
Dothiepin Spectrum
113-53-1, DothiepinRelated Search:
  • Sulfur & Selenium Compounds
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Amines
  • Chemical Amines
  • 抑制剂
  • 医药原料
  • 神经系统用药
  • 度硫平
  • 多硫平-D3马来酸盐
  • 度琉平
  • 113-53-1
  • Dothiepin-d3 Maleate
  • 3-(6,11-dihydrodibenzo(b,e)thiepin-11-ylidene)propyldimethylamine
  • DOTHIEPIN
  • N,N-Dimethyl- dibenzo[b,e]thiepin-11(6H),-propylamine
  • 3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine
  • CIS,TRANS-DOTHIEPIN,1.0MG/MLINMETHANOL
  • Methiaden
  • Dolsulepine
  • DOTHIEPIN,3-DIBENZO[B,E] THIEPIN-11-(6H)-YLIDENE-N,N-DIMETHYL-PROPONAMINE
  • 3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-diMethyl-
  • Dothiepin (cis/trans)
  • (E)-3-[Dibenzo[b,e]thiepin-11(6H)-ylidene]-N,N-dimethylpropane-1-amine
  • (E)-3-[Dibenzo[b,e]thiepin-11(6H)-ylidene]-N,N-dimethyl-1-propanamine
  • 3-DIBENZO[B,E] THIEPIN-11-(6H)-YLIDENE-N,N-DIMETHYL-PROPONAMINE
  • Prothiadene
  • Prothiaden spofa
  • Prothiaden
  • Propylamine, N,N-dimethyl-3-(dibenzo(b,e)thiepin-delta-sup(11(6H),gamma))-
  • N,N-Dimethyldibenzo(b,e)thiepin-delta-sup(11(6H),gamma)propylamine
  • n,n-dimethyl-3-(dibenzo(b,e)thiepin-delta-sup(11(6h),gamma))-propylamin
  • iz914
  • IZ 914
  • Dothep
  • Dosulepine
  • dosulepin
  • Dibenzo[b,e]thiepin-delta11(6H),gamma-propylamine, N,N-dimethyl-
  • Dibenzo[b,e]thiepin, 1-propanamine deriv.
  • 3-Dibenzo[b,e]thiepin-11(6H)-ylidine-N,N-dimethyl-propanamine
  • 3-dibenzo(b,e)thiepin-11(6h)-ylidene-n,n-dimethyl-1-propanamin
  • 3-Dibenzo(b,e)thiepin-11(6H)-ylidene-N,N-dimethyl-1-propamine
  • 1-Propanamine, 3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-
  • 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin
  • (3E)-3-Dibenzo[b,E]thiepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine

Home

My