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DRB

DRB Structure
DRB
  • CAS No.53-85-0
  • Chemical Name:DRB
  • CBNumber:CB0367110
  • Molecular Formula:C12H12Cl2N2O4
  • Formula Weight:319.14
  • MOL File:53-85-0.mol
DRB Property
  • Melting point 222-224°C
  • Boiling point 606.2±65.0 °C(Predicted)
  • Density 1.5917 (rough estimate)
  • refractive index 1.6200 (estimate)
  • storage temp. -20°C
  • solubility Soluble in DMSO (up to 20 mg/ml)
  • pka 13.23±0.70(Predicted)
  • form White solid
  • color White
  • Water Solubility Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer saline, water, methanol and pyridine. Slightly soluble in aqueous buffers.
  • λmax 296nm(lit.)
  • BRN 39123
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
  • InChIKey XHSQDZXAVJRBMX-AYLPWXGPSA-N
  • CAS DataBase Reference 53-85-0
  • FDA UNII 8153319T3Q
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Safety Statements  :24/25
  • WGK Germany  :3
  • RTECS  :DD7310000
  • HS Code  :29349990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P305+P351+P338
DRB Price More Price(5)
  • Brand: Sigma-Aldrich(India)
  • Product number: D1916
  • Product name : 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside
  • Purity: 
  • Packaging: 10MG
  • Price: ₹7166.15
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D1916
  • Product name : 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside
  • Purity: 
  • Packaging: 50MG
  • Price: ₹21000.5
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 287891
  • Product name : 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem
  • Purity: A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC?? = 6 μM).
  • Packaging: 50MG
  • Price: ₹17860
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D4292
  • Product name : 5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside
  • Purity: 
  • Packaging: 100MG
  • Price: ₹5700
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D4292
  • Product name : 5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside
  • Purity: 
  • Packaging: 1G
  • Price: ₹19800
  • Updated: 2022/05/26
  • Buy: Buy

DRB Chemical Properties,Usage,Production

  • Description DRB (53-85-0) is a classic inhibitor of transcription by RNA polymerase II.?A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for processive transcription elongation by RNA polymerase II.1,2?Also inhibits casein kinase II, IC50=4-10 μM.?3?Suppresses the SIRT1/CK2α pathway and enhances the radiosensitivity of human cancer cells.4?Kinase-independent activities of Cdk9 such as glucocorticoid receptor modulation are not inhibited by DRB.5
  • Chemical Properties White Solid
  • Uses 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside has been used:
    • as an inhibitor of RNA polymerase II in mouse melanoma cells
    • for the inhibition of cyclin D1 mRNA synthesis in human prostate epithelial cell lines
    • in the inhibition of interleukin-2 gene transcription in Jurkat cells

  • Uses DRB is an inhibitor of RNA synthesis (causes premature termination of transcription).
  • Uses Inhibits casein kinase II and blocks RNA synthesis. An adenosine analog.5,6-Dichlorobenzimidazole riboside is used as an inhibitor of RNA Polymerase II. It is nucleoside analogue and used in research to study the mechanisms of cellular regulation. Further, it inhibits some protein kinases.
  • Biochem/physiol Actions 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), a nucleoside analog that halts mRNA synthesis by phosphorylation of the C-terminal domain of RNA polymerase II, making it inactive. It also interferes with the DNA topoisomerase II, may modulate response to cytokines and blocks the human immunodeficiency virus (HIV) via RNA modification. It also inhibits cyclin-dependent kinases (CDKs) 7 and 9 and favors apoptosis in leukemic cells. It may serve as a therapeutic agent in treating cancer.
  • in vivo

    5,6-Dichlorobenzimidazole riboside (2.0-3.0 mg/0.25 mL water, ?intraperitoneally injected twice a day for 5 days) does not inhibit the multiplication of the PR8 strain of influenza virus in mice[7].

  • References 1) Baumli?et al.?(2010),?Halogen bonds form the basis for selective P-TEFb inhibition by DRB; Chem. Biol.,?17?931 2) Yamaguchi?et al.?(1998),?Interplay between positive and negative elongation factors: drawing a new view of DRB; Genes Cells,?3?9 3) Zandomeni (1989), Kinetics of inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole; Biochem.J., 262 469 4) Wang?et al.?(2014),?Inhibition of P-TEFb by DRB suppresses SIRT1/CK2α pathway and enhances radiosensitivity of human cancer cells; Anticancer Res.,?34?6981 5) Zhu?et al.?(2014),?A kinase-independent activity of Cdk9 modulates glucocorticoid receptor-mediated gene induction; Biochemistry,?53?1753
DRB Preparation Products And Raw materials
Raw materials
Preparation Products
DRB Suppliers
Global(112)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
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    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
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  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
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  • Supplier：
    NewCan Biotech Limited
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  • Email：sales@newcanbio.com
  • Country：China
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  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
DRB Spectrum
53-85-0, DRBRelated Search:
  • Nucleotides
  • Inhibitors
  • Bases & Related Reagents
  • 抑制剂
  • Cell Signaling and Neuroscience
  • Carbohydrate Synthesis
  • Cell Biology
  • BioChemical
  • Specialty Synthesis
  • Monosaccharides
  • Gene Regulation and Expression
  • DNA-RNA Transcription Regulators
  • C12H12Cl2N2O4
  • 二氯苯并咪唑呋喃型核糖苷,10 MM DMSO 溶液
  • DRB (BENZIMIDAZOLE),CASEIN KINASE II抑制剂
  • 化学试剂/5,6-二氯苯并咪唑-1-Β-D-呋喃核苷/提供COA报告
  • 5,6-二氯-1-Β-D-呋喃核糖基-苯并咪唑
  • 5,6-二氯苯并咪唑 核糖甙
  • (2R,3R,4S,5R)-2-(5,6-二氯-1H-苯并[D]咪唑-1-基)-5-(羟甲基)四氢呋喃-3,4-二醇
  • 二氯苯并咪唑呋喃型核糖苷
  • 5,6-二氯-1-Β-D-呋喃核糖基苯并咪唑
  • 5,6-二氯苯并咪唑 核糖甙,98%
  • 5,6-二氯苯并咪唑-1-Β-D-呋喃核苷
  • 5,6-二氯苯并咪唑1-Β-D-次黄嘌呤
  • 53-85-0
  • 5,6-Dichlorobenzimidazole 1-β-<sc>D</sc>-ribofuranoside
  • DRB, 10 mM in DMSO
  • DRB (Benzimidazole), Casein kinase II inhibitor
  • ,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside
  • 5,6-dichloro-1-β-D-ribobenzimidazole
  • 1H-Benzimidazole,5,6-dichloro-1-b-D-ribofuranosyl-
  • 5,6-Dichlorobenzimidazole riboside(DBR)
  • 5,6-Dichlorobenzimidazole riboside,DRB,inhibit,Inhibitor,CDK,Cyclin dependent kinase
  • 5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole
  • 1H-Benzimidazole, 5,6-dichloro-1-β-D-ribofuranosyl-
  • 5,6-Dichloro-1-(beta-D-ribofuranosyl)-1H-benzimidazole
  • 5,6-Dichlorobenzimidazole1-β-D-Ribofuranoside&gt
  • 5,6-Dichlororibofuranosylbenzimidazole
  • 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem
  • 5,6-DICHLOROBENIMIDAZOLE-1-B-D- RIBOFURANOSIDE
  • (2R,3R,4S,5R)-2-(5,6-Dichloro-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • DRB USP/EP/BP
  • DBR
  • DRB
  • DRB (Benzimidazole)
  • 5,6-DICHLORO-BETA-D-RIBOFURANOSYL-BENZIMIDAZOLE
  • 5,6-DICHLOROBENZIMIDAZOLE RIBOSIDE
  • 5,6-DICHLOROBENZIMIDAZOLE-1-BETA-D-RIBOFURANOSIDE
  • 4,5-dichloro-2-(3-methylbenzyl)pyridazin-3(2h)-one
  • NSC 401575
  • 1-β-D-Ribofuranosyl-5,6-dichlorobenziMidazole
  • 5,6-Dichlorobenzimidazole-1-β-D-ribofuranoside ,98%
  • DBR, 5,6-Dichlorobenzimidazole 1--D-ribofuranoside
  • 5,6-Dichloropurine-1--D-ribofuanosyl-H-benzimidazole
  • 5,6-DICHLOROBENZIMIDAZOLE RIBOSIDE (DRB)98%
  • 5,6-DICHLOROBENZIMIDAZOLE RIBOSIDE 98%
  • 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole, 5,6-Dichlorobenzimidazole riboside, DRB
  • 5,6-Dichlorobenzimidazole-1-b-D-ribofuranoside

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