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3-Aminobenzeneboronic acid hemisulfate salt

CAS No.66472-86-4
Chemical Name:3-Aminobenzeneboronic acid hemisulfate salt
CBNumber:CB0357728
Molecular Formula:C12H18B2N2O8S
Formula Weight:371.96692
MOL File:66472-86-4.mol

3-Aminobenzeneboronic acid hemisulfate salt Property

Melting point ≥300 °C
storage temp. Inert atmosphere,2-8°C
Water Solubility Soluble in water
form Crystalline Powder
color White to slightly beige
Sensitive Hygroscopic
BRN 8094151
InChIKey XMVGYYBQCXVVHU-UHFFFAOYSA-N
CAS DataBase Reference 66472-86-4
UNSPSC Code 12352103
NACRES NA.22

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36-37/39
WGK Germany :3
F :3-10
HazardClass :IRRITANT
HS Code :29310095

NFPA 704:

	1
2

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319
Precautionary statements P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313

3-Aminobenzeneboronic acid hemisulfate salt Price More Price(5)

Brand: Sigma-Aldrich(India)
Product number: A71751
Product name : 3-Aminophenylboronic acid hemisulfate salt
Purity: ≥95%
Packaging: 5G
Price: ₹7220.28
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: A71751
Product name : 3-Aminophenylboronic acid hemisulfate salt
Purity: ≥95%
Packaging: 25G
Price: ₹26694.45
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A1774
Product name : 3-Aminophenylboronic Acid Hemisulfate
Purity:
Packaging: 1G
Price: ₹2800
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A1774
Product name : 3-Aminophenylboronic Acid Hemisulfate
Purity:
Packaging: 5G
Price: ₹7100
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A1774
Product name : 3-Aminophenylboronic Acid Hemisulfate
Purity:
Packaging: 25G
Price: ₹17500
Updated: 2022/05/26
Buy: Buy

3-Aminobenzeneboronic acid hemisulfate salt Chemical Properties,Usage,Production

Chemical Properties White to slightly beige crystalline powder
Uses 3-Aminobenzeneboronic acid hemisulfate salt is a boronic acid derivative, which can be used as an intermediate in pharmaceutical synthesis. Adsorbent additive for the chromatographic separation of 3'-terminal polynucleotides from RNA.
Application 3-Aminophenylboronic acid hemisulfate salt is used in the synthesis of:
Phenylboronic acid-functionalized inverse opal hydrogels within microfluidic flow cells for glucose sensing.
Phenylboronic acid-salicylhydroxamic acid-derived complexing reagent for protein immobilization on chromatographic support.
It can also be used in the preparation of phenylboronic acid (PBA) monolayer-modified Au electrode for the voltammetric sensing of uridine and cytidine.
Preparation 3-Aminobenzeneboronic acid hemisulfate salt synthesis: Benzenamine, 3-bromo-N-(diphenylmethylene)- (80,0 g; 0.24 moles) was added to the cryogenic reactor along with 1.4 equivalents of triisopropyl borate and dissolved in tetrahydrofuran. The resulting solution was cooled to -80°C under an inert atmosphere and 1.35 equivalents of n-butyllithium (as a solution in n-hexane) was added maintaining the internal temperature. When complete conversion was achieved, the reaction mixture was added to a dilute mixture of sulfuric acid (1 M) and toluene. The layers were separated to obtain an aqueous solution of 3-aminophenylboronic acid hydrogen sulfate (assay yield: 85%). 3-Aminobenzeneboronic acid hemisulfate salt can be obtained by precipitating a 0.5 M aqueous solution at pH 7.2 (pH corrected with 33% aqueous NaOH) at a temperature of 0-5°C. Filtration and drying under vacuum at 40°C for 8 hours yielded 21.7 g of 3-Aminobenzeneboronic acid hemisulfate salt (0.16 moles; 66% molar yield).