ChemicalBook > CAS DataBase List > Diflorasone

Diflorasone

Diflorasone Structure
Diflorasone
  • CAS No.2557-49-5
  • Chemical Name:Diflorasone
  • CBNumber:CB0320407
  • Molecular Formula:C22H28F2O5
  • Formula Weight:410.46
  • MOL File:2557-49-5.mol
Diflorasone Property
  • Melting point 228-239°C
  • Boiling point 569.8±50.0 °C(Predicted)
  • Density 1.36±0.1 g/cm3(Predicted)
  • storage temp. Refrigerator
  • solubility Methanol (Slightly)
  • pka 11.98±0.70(Predicted)
  • form Solid
  • color Off-White to Pale Yellow
  • CAS DataBase Reference 2557-49-5
  • FDA UNII T2DHJ9645W
  • ATC code D07AC10
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H312-H361
  • Precautionary statements P280-P302+P352-P312-P322-P363-P501-P201-P202-P281-P308+P313-P405-P501

Diflorasone Chemical Properties,Usage,Production

  • Chemical Properties Off-White Solid
  • Originator Florone,Upjohn,US,1978
  • Uses An anti-inflammatory and anti-itching corticosteroid usually present in topical creams.
  • Definition ChEBI: The 16beta-analogue of flumethasone. It is used as the 17,21-diacetate as a topical anti-inflammatory and antipruritic in the treatment of various skin disorders.
  • Manufacturing Process 6α-Fluoro-9β-epoxy-17α,21-dihydroxy-16α-methyl-1,4-pregnadiene-3,20- dione-21-acetate:To a solution of 6.78 g of 6α-fluoro-9α-bromo-11β,17α,21- trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione-21-acetate in 175 ml of acetone was added 6.78 g of potassium acetate and the resulting suspension was heated under reflux for a period of 17 hours. The mixture was then concentrated to approximately 60 ml volume at reduced pressure on the steam bath, diluted with water and extracted with methylene chloride. The methylene chloride extracts were combined, washed with water, dried over anhydrous sodium sulfate and evaporated. The residue was redissolved in methylene chloride and chromatographed over 500 g of Florisil anhydrous magnesium silicate. The column was eluted with 1 liter portions of hexanes (Skellysolve B) containing increasing proportions of acetone. There was so eluted 6α-fluoro-9β,11β-epoxy-16α-methyl-17α,21-dihydroxy-1,4- pregnadiene-3,20-dione-21-acetate which was freed of solvent by evaporation of the eluates.
    6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20- dione-2-1-acetate: To approximately 1.3 g of hydrogen fluoride contained in a polyethylene bottle and maintained at -60C was added 2.3 ml of tetrahydrofuran and then a solution of 500 mg (0,0012 mol) of 6α-fluoro9β,11β-epoxy-16α-methyl-17α,21-dihydroxy-1,4-pregnadiene-3,20-dione-21- acetate in two ml of methylene chloride. The steroid solution was rinsed in with an additional 1 ml of methylene chloride. The light red colored solution was then kept at approximately -30°C for 1 hour and at -10°C for 2 hours. At the end of this period it was mixed cautiously with an excess of cold sodium bicarbonate solution and the organic material extracted with the aid of additional methylene chloride.
    The combined extracts were washed with water, dried over anhydrous sodium sulfate and concentrated to approximately 35 ml. The solution was chromatographed over 130 g of Florisil anhydrous magnesium silicate. The column was developed with 260 ml portions of hexanes (Skellysolve B) containing increasing proportions of acetone. There was thus eluted 6α,9αdifluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione-21- acetate which was freed of solvent by evaporation of the eluate fractions.
    6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20- dione: 3.25 g of 6α,9α-difluoro-11β,17α,21-trihydroxy-16α-methyl-1,4- pregnadiene-3,20-dione-21-acetate was dissolved in 325 ml of methanol, previously purged of air-oxygen by passing nitrogen through it for 10 minutes and thereto was added a solution of 1.63 g of potassium bicarbonate in 30 ml of water, similarly purged of oxygen. The mixture was allowed to stand at room temperature for a period of 5 hours in a nitrogen atmosphere, thereupon neutralized with 2.14 ml of acetic acid in 40 ml of water. The mixture was concentrated to approximately one-third volume at reduced pressure on a 60°C water bath. Thereupon 250 ml of water was added and the mixture chilled. The crystalline product was collected on a filter, washed with water and dried to give 6α,9α-difluoro-11β,17α,21-trihydroxy-16αmethyl-1,4-pregnadiene-3,20-dione.
    The diflorasone is reacted with orthoacetic acid trimethyl ester in the presence of toluenesulfonic acid to give diflorasone diacetate.
  • brand name Florone (Pharmacia & Upjohn); Psorcon (Pharmacia & Upjohn); Psorcon (Sanofi Aventis).
  • Therapeutic Function Antiinflammatory
Diflorasone Preparation Products And Raw materials
Raw materials
Preparation Products
Diflorasone Suppliers
Global(214)Suppliers
  • Supplier：
    Moxin Chemicals
  • Tel： +8617320513646
  • Email：Anna@molcoo.com
  • Country：China
  • ProdList：9434
  • Advantage：58
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29859
  • Advantage：58
  • Supplier：
    Xiamen AmoyChem Co., Ltd
  • Tel：+86-86-5926051114<br/>+8615060885618
  • Email：sales@amoychem.com
  • Country：China
  • ProdList：6383
  • Advantage：58
Diflorasone Spectrum
2557-49-5, DiflorasoneRelated Search:
  • Steroids
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Inhibitors
  • 抑制剂
  • 药靶配体
  • 化工原料
  • 科研精品试剂
  • 甾体类原料中间体
  • 定制系列
  • 柏锦生物
  • 甾体类原料-糖皮质激素
  • 科研原料
  • 化学试剂
  • 医药原料药
  • 有机中间体
  • 医药、农药及染料中间体
  • 科研试剂
  • 甾体激素原料药
  • 原料药
  • 小分子抑制剂，天然产物
  • 医药原料
  • 小分子抑制剂
  • 甾体类
  • 食品添加剂
  • 二氟拉松,10 MM DMSO 溶液
  • (6S,8S,10S,11S,13S,14S,16S,17R)-6,9-二氟-11,17-二羟基-17-(2-羟基乙酰基)-10,13,16-三甲基-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊并[A]菲-3-酮
  • PERFEMIKER]二氟拉松,98%
  • 地弗拉松
  • 二氟拉松 标准品
  • 二氟拉松:双氟拉松
  • 双氟拉松
  • 二氟拉松
  • 2557-49-5
  • Fluticasone Propionate Impurity 28
  • Diflorasone, 10 mM in DMSO
  • (6S,8S,10S,11S,13S,14S,16S,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16β)-
  • Diflorasone USP/EP/BP
  • 11β,17α,21-trihydroxy-6α,9α-difluoro-16β-methylpregna-1,4-diene-3,20-dione
  • Diflorasone [INN:BAN]
  • Difloasone
  • (6α,11β,16β)-6,9-Difluoro-11,17,21-trihydroxy-16-Methyl-pregna-1,4-diene-3,20-dione
  • (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
  • (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
  • (6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
  • DIFLORASONE
  • (6s,8s,9s,10s,11s,13s,14s,16s,17r)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

Home

My